ID REV_HV2D1 STANDARD; PRT; 103 AA. AC P17754; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1990, sequence version 1. DT 30-MAY-2006, entry version 40. DE REV protein (Anti-repression transactivator protein) (ART/TRS). GN Name=REV; OS Human immunodeficiency virus type 2 (isolate D194) (HIV-2). OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11713; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=89184631; PubMed=2467304; RA Kuehnel H., von Briesen H., Dietrich U., Adamski M., Mix D., RA Biesert L., Kreutz R., Immelmann A., Henco K., Meichsner C., RA Andreesen R., Gelderblom H., Ruebsamen-Waigmann H.; RT "Molecular cloning of two west African human immunodeficiency virus RT type 2 isolates that replicate well in macrophages: a Gambian isolate, RT from a patient with neurologic acquired immunodeficiency syndrome, and RT a highly divergent Ghanian isolate."; RL Proc. Natl. Acad. Sci. U.S.A. 86:2383-2387(1989). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=91045094; PubMed=2235509; RA Kuehnel H., Kreutz R., Ruebsamen-Waigmann H.; RT "Nucleotide sequence of HIV-2D194, an isolate from a Gambian case of RT 'neuro-AIDS', which showed excellent growth in macrophages."; RL Nucleic Acids Res. 18:6142-6142(1990). CC -!- FUNCTION: Rev appears to act post-transcriptionally to relieve CC negative repression of Gag and Env production. CC -!- SUBCELLULAR LOCATION: Nucleus; nucleolus. Accumulates in the CC nucleoli. CC -!- PTM: Phosphoprotein whose state of phosphorylation is mediated by CC a specific serine kinase activity present in the nucleus. CC -!- MISCELLANEOUS: This isolate is from a Gambian case of 'neuro- CC AIDS'. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J04542; AAA76846.1; -; Genomic_DNA. DR EMBL; X52223; CAA36470.1; -; Genomic_DNA. DR PIR; S12158; S12158. DR HIV; J04542; REV$2D194. DR InterPro; IPR000625; REV_protein. DR Pfam; PF00424; REV; 1. KW AIDS; Nuclear protein; Phosphorylation; Transcription; KW Transcription regulation. FT CHAIN 1 103 REV protein. FT /FTId=PRO_0000085281. SQ SEQUENCE 103 AA; 11963 MW; 607BEF9A5B36E7A0 CRC64; MRDRADEEGL QEKLRLIRLL HQINPYPHGQ GTASQRRNRR RRRRRQWFRL VALATKLHTI PDPPTDSPLD RAIQQLQGLT IQELPDPPTD LPESNSNQGL AET //