ID REV$HIV21 STANDARD; PRT; 103 AA. AC P17754; DT 01-AUG-1990 (REL. 15, CREATED) DT 01-AUG-1990 (REL. 15, LAST SEQUENCE UPDATE) DT 01-FEB-1991 (REL. 17, LAST ANNOTATION UPDATE) DE REV PROTEIN (ANTI-REPRESSION TRANSACTIVATOR PROTEIN) (ART/TRS). OS HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 (HIV-2) (ISOLATE D194). OC VIRIDAE; SS-RNA ENVELOPED VIRUSES; POSITIVE-STRAND; RETROVIRIDAE; OC LENTIVIRINAE. RN [1] (SEQUENCE FROM N.A.) RA KUEHNEL H., VON BRIESEN H., DIETRICH U., ADAMSKI M., MIX D., RA BIESERT L., KREUTZ R., IMMELMANN A., HENCO K., MEICHSNER C., RA ANDREESEN R., GELDERBLOM H., RUEBSAMEN-WAIGMANN H.; RL PROC. NATL. ACAD. SCI. U.S.A. 86:2383-2387(1989). CC -!- FUNCTION: REV APPEARS TO ACT POST-TRANSCRIPTIONALLY TO RELIEVE CC NEGATIVE REPRESSION OF GAG AND ENV PRODUCTION. CC -!- SUBCELLULAR LOCATION: NUCLEAR PROTEIN THAT ACCUMULATES IN THE CC NUCLEOLI. CC -!- REV IS A PHOSPHOPROTEIN WHOSE STATE OF PHOSPHORYLATION IS MEDIATED CC BY A SPECIFIC SERINE KINASE ACTIVITY PRESENT IN THE NUCLEUS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J04542; HIV2D194. DR HIV; J04542; REV$2D194. KW TRANSCRIPTION REGULATION; AIDS; PHOSPHORYLATION; NUCLEAR PROTEIN. SQ SEQUENCE 103 AA; 11962 MW; 49327 CN; MRDRADEEGL QEKLRLIRLL HQINPYPHGQ GTASQRRNRR RRRRRQWFRL VALATKLHTI PDPPTDSPLD RAIQQLQGLT IQELPDPPTD LPESNSNQGL AET //