ID REV_HV2D1 STANDARD; PRT; 103 AA. AC P17754; DT 01-AUG-1990 (Rel. 15, Created) DT 01-AUG-1990 (Rel. 15, Last sequence update) DT 01-JUL-1993 (Rel. 26, Last annotation update) DE REV PROTEIN (ANTI-REPRESSION TRANSACTIVATOR PROTEIN) (ART/TRS). GN REV. OS Human immunodeficiency virus type 2 (isolate D194) (HIV-2). OC Viruses; Retroid viruses; Retroviridae; Lentivirus. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 89184631. RA Kuehnel H., von Briesen H., Dietrich U., Adamski M., Mix D., RA Biesert L., Kreutz R., Immelmann A., Henco K., Meichsner C., RA Andreesen R., Gelderblom H., Ruebsamen-Waigmann H.; RT "Molecular cloning of two west African human immunodeficiency virus RT type 2 isolates that replicate well in macrophages: a Gambian RT isolate, from a patient with neurologic acquired immunodeficiency RT syndrome, and a highly divergent Ghanian isolate."; RL Proc. Natl. Acad. Sci. U.S.A. 86:2383-2387(1989). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 91045094. RA Kuehnel H., Kreutz R., Ruebsamen-Waigmann H.; RT "Nucleotide sequence of HIV-2D194, an isolate from a Gambian case of RT 'neuro-AIDS', which showed excellent growth in macrophages."; RL Nucleic Acids Res. 18:6142-6142(1990). CC -!- FUNCTION: REV APPEARS TO ACT POST-TRANSCRIPTIONALLY TO RELIEVE CC NEGATIVE REPRESSION OF GAG AND ENV PRODUCTION. CC -!- SUBCELLULAR LOCATION: NUCLEAR; ACCUMULATES IN THE NUCLEOLI. CC -!- PTM: PHOSPHOPROTEIN WHOSE STATE OF PHOSPHORYLATION IS MEDIATED CC BY A SPECIFIC SERINE KINASE ACTIVITY PRESENT IN THE NUCLEUS. CC -!- MISCELLANEOUS: THIS ISOLATE IS FROM A GAMBIAN CASE OF CC 'NEURO-AIDS'. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J04542; AAA76846.1; -. DR EMBL; X52223; CAA36470.1; -. DR PIR; S12158; S12158. DR HIV; J04542; REV$2D194. DR INTERPRO; IPR000625; -. DR PFAM; PF00424; REV; 1. KW Transcription regulation; AIDS; Phosphorylation; Nuclear protein. SQ SEQUENCE 103 AA; 11962 MW; 607BEF9A5B36E7A0 CRC64; MRDRADEEGL QEKLRLIRLL HQINPYPHGQ GTASQRRNRR RRRRRQWFRL VALATKLHTI PDPPTDSPLD RAIQQLQGLT IQELPDPPTD LPESNSNQGL AET //