ID REV_HV2D1 STANDARD; PRT; 103 AA. AC P17754; DT 01-AUG-1990 (REL. 15, CREATED) DT 01-AUG-1990 (REL. 15, LAST SEQUENCE UPDATE) DT 01-JUL-1993 (REL. 26, LAST ANNOTATION UPDATE) DE REV PROTEIN (ANTI-REPRESSION TRANSACTIVATOR PROTEIN) (ART/TRS). GN REV. OS HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 (ISOLATE D194) (HIV-2). OC VIRIDAE; SS-RNA ENVELOPED VIRUSES; POSITIVE-STRAND; RETROVIRIDAE; OC LENTIVIRINAE. RN [1] RP SEQUENCE FROM N.A. RM 89184631 RA KUEHNEL H., VON BRIESEN H., DIETRICH U., ADAMSKI M., MIX D., RA BIESERT L., KREUTZ R., IMMELMANN A., HENCO K., MEICHSNER C., RA ANDREESEN R., GELDERBLOM H., RUEBSAMEN-WAIGMANN H.; RL PROC. NATL. ACAD. SCI. U.S.A. 86:2383-2387(1989). RN [2] RP SEQUENCE FROM N.A. RM 91045094 RA KUEHNEL H., KREUTZ R., RUEBSAMEN-WAIGMANN H.; RL NUCLEIC ACIDS RES. 18:6142-6142(1990). CC -!- FUNCTION: REV APPEARS TO ACT POST-TRANSCRIPTIONALLY TO RELIEVE CC NEGATIVE REPRESSION OF GAG AND ENV PRODUCTION. CC -!- SUBCELLULAR LOCATION: NUCLEAR; ACCUMULATES IN THE NUCLEOLI. CC -!- PTM: PHOSPHOPROTEIN WHOSE STATE OF PHOSPHORYLATION IS MEDIATED CC BY A SPECIFIC SERINE KINASE ACTIVITY PRESENT IN THE NUCLEUS. CC -!- THIS ISOLATE IS FROM A GAMBIAN CASE OF 'NEURO-AIDS'. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J04542; HIV2D194. DR EMBL; X52223; HIVD194. DR PIR; S12158; S12158. DR HIV; J04542; REV$2D194. KW TRANSCRIPTION REGULATION; AIDS; PHOSPHORYLATION; NUCLEAR PROTEIN. SQ SEQUENCE 103 AA; 11962 MW; 49327 CN; MRDRADEEGL QEKLRLIRLL HQINPYPHGQ GTASQRRNRR RRRRRQWFRL VALATKLHTI PDPPTDSPLD RAIQQLQGLT IQELPDPPTD LPESNSNQGL AET //