ID UL31_HCMVA Reviewed; 595 AA. AC P16848; Q7M6Q2; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 15-FEB-2005, sequence version 2. DT 13-FEB-2019, entry version 47. DE RecName: Full=Protein UL31 {ECO:0000305}; DE Flags: Precursor; GN Name=UL31 {ECO:0000303|PubMed:29937271}; OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5). OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Betaherpesvirinae; Cytomegalovirus. OX NCBI_TaxID=10360; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=2161319; RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.; RT "Analysis of the protein-coding content of the sequence of human RT cytomegalovirus strain AD169."; RL Curr. Top. Microbiol. Immunol. 154:125-169(1990). RN [2] RP GENOME REANNOTATION. RX PubMed=12533697; DOI=10.1099/vir.0.18606-0; RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RT "The human cytomegalovirus genome revisited: comparison with the RT chimpanzee cytomegalovirus genome."; RL J. Gen. Virol. 84:17-28(2003). RN [3] RP ERRATUM. RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RL J. Gen. Virol. 84:1053-1053(2003). RN [4] RP FUNCTION, INTERACTION WITH HOST CGAS, AND SUBCELLULAR LOCATION. RX PubMed=29937271; DOI=10.1016/j.chom.2018.05.007; RA Huang Z.F., Zou H.M., Liao B.W., Zhang H.Y., Yang Y., Fu Y.Z., RA Wang S.Y., Luo M.H., Wang Y.Y.; RT "Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to RT Mediate Immune Evasion."; RL Cell Host Microbe 24:69-80(2018). CC -!- FUNCTION: Plays a role in the inhibition of host innate immune CC system by targeting host CGAS and promoting dissociation of DNA CC from CGAS, thereby inhibiting the enzymatic activity of CGAS. CC {ECO:0000269|PubMed:29937271}. CC -!- SUBUNIT: Interacts with host CGAS. {ECO:0000269|PubMed:29937271}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm CC {ECO:0000269|PubMed:29937271}. Host nucleus CC {ECO:0000269|PubMed:29937271}. CC -!- SIMILARITY: Belongs to the herpesviridae U10 family. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAA35430.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17403; CAA35430.1; ALT_INIT; Genomic_DNA. DR EMBL; BK000394; DAA00136.1; -; Genomic_DNA. DR PIR; S09794; S09794. DR Proteomes; UP000008991; Genome. DR Proteomes; UP000008992; Genome. DR GO; GO:0030430; C:host cell cytoplasm; IDA:UniProtKB. DR GO; GO:0042025; C:host cell nucleus; IDA:UniProtKB. DR GO; GO:0039503; P:suppression by virus of host innate immune response; IDA:UniProtKB. DR InterPro; IPR007578; Herpes_U10. DR Pfam; PF04489; DUF570; 1. PE 1: Evidence at protein level; KW Complete proteome; Glycoprotein; Host cytoplasm; Host nucleus; KW Host-virus interaction; KW Inhibition of host innate immune response by virus; KW Reference proteome; Signal; Viral immunoevasion. FT SIGNAL 1 23 {ECO:0000255}. FT CHAIN 24 595 Protein UL31. FT /FTId=PRO_0000038314. FT CARBOHYD 176 176 N-linked (GlcNAc...) asparagine; by host. FT {ECO:0000255}. FT CARBOHYD 197 197 N-linked (GlcNAc...) asparagine; by host. FT {ECO:0000255}. SQ SEQUENCE 595 AA; 65748 MW; 8E252FA818E6F715 CRC64; MGDKPTLVTL LTVAVSSPPP SSPLPLVSFT ELLLPPPSVA AAAVAATATS EVGEKTAEQE VAAADPETGN ERRENRENEG GETRTTGTTA VKRSHDGIPR QLAERLRLCR HMDPEQDYRL PAQDVVTSWI EALRDADRDN YGRCVRHAKI HRSASHLTAY ESYLVSITEQ YNTASNVTEK ASYVQGCIFL SFPVIYNNTQ GCGYKYDWSN VVTPKAAYAE LFFLLCSTSE SSVVLQPLIT KGGLCSSMAV YDEETMRQSQ AVQIGFLHTQ LVMVPFVPHA CPHYAVPFTT PGKPGCGGAP SGVAGLEEAA PFGRVSVTRH GATLLCRVDH LTWISKRVTT YGHKKITRYL AQFRGTMDDD EAALPGEDEA WIASKNVQYE FMGLIFTVNV DSLCVDAEQR QLLGTVATSF CHRVSDKITA RNMPRAFSFY LLTSAQRGYD LRFSRNPSLF FSGDALNCPL LNEPNVFSLT VHAPYDIHFG VQPRQTVELD LRYVQITDRC FLVANLPHED AFYTGLSVWR GGEPLKVTLW TRTRSIVIPQ GTPIATLYQI TEGDGNVYSY NHHTVFRQMH AAGTTTFFLG DMQLPADNFL TSPHP //