ID   GL_HCMVA                Reviewed;         278 AA.
AC   P16832; Q7M6S9;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   16-MAY-2012, entry version 60.
DE   RecName: Full=Envelope glycoprotein L;
DE            Short=gL;
DE   Flags: Precursor;
GN   Name=GL; Synonyms=UL115;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=90269039; PubMed=2161319;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=22255414; PubMed=12368327;
RX   DOI=10.1128/JVI.76.21.10841-10848.2002;
RA   Rasmussen L., Geissler A., Cowan C., Chase A., Winters M.;
RT   "The genes encoding the gCIII complex of human cytomegalovirus exist
RT   in highly diverse combinations in clinical isolates.";
RL   J. Virol. 76:10841-10848(2002).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Isolate 650, and Isolate 813;
RX   MEDLINE=22421467; PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J.,
RA   Alcendor D.J., McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the
RT   chimpanzee cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [4]
RP   ERRATUM.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J.,
RA   Alcendor D.J., McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [5]
RP   IDENTIFICATION IN A COMPLEX WITH GO AND GH.
RX   PubMed=9733861;
RA   Huber M.T., Compton T.;
RT   "The human cytomegalovirus UL74 gene encodes the third component of
RT   the glycoprotein H-glycoprotein L-containing envelope complex.";
RL   J. Virol. 72:8191-8197(1998).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=15452216; DOI=10.1128/JVI.78.20.10960-10966.2004;
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RT   "Identification of proteins in human cytomegalovirus (HCMV) particles:
RT   the HCMV proteome.";
RL   J. Virol. 78:10960-10966(2004).
RN   [7]
RP   ERRATUM.
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RL   J. Virol. 78:13395-13395(2004).
CC   -!- FUNCTION: The heterodimer glycoprotein H-glycoprotein L is
CC       required for the fusion of viral and plasma membranes leading to
CC       virus entry into the host cell. Membrane fusion is mediated by the
CC       fusion machinery composed at least of gB and the heterodimer
CC       gH/gL.
CC   -!- SUBUNIT: Interacts with glycoprotein H (gH). Forms a complex with
CC       gH, UL128, UL130 and UL131 that mediates efficient entry into host
CC       epithelial and endothelial cells.
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Peripheral membrane
CC       protein; Extracellular side (By similarity). Host cell membrane;
CC       Peripheral membrane protein; Extracellular side (By similarity).
CC       Note=gL is not anchored to the viral envelope, but associates with
CC       the extravirion surface through its binding to gH (By similarity).
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein L family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA35317.1; Type=Erroneous initiation;
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DR   EMBL; X17403; CAA35317.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AF530171; AAM96168.1; -; Genomic_DNA.
DR   EMBL; AF530172; AAM96169.1; -; Genomic_DNA.
DR   EMBL; AF530173; AAM96170.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00105.1; -; Genomic_DNA.
DR   PIR; S09882; S09882.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016032; P:viral reproduction; IEA:InterPro.
DR   InterPro; IPR002689; Cytomegalo_gL.
DR   Pfam; PF01801; Cytomega_gL; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Fusion of virus membrane with host cell membrane;
KW   Fusion of virus membrane with host membrane; Glycoprotein;
KW   Host cell membrane; Host membrane; Initiation of viral infection;
KW   Membrane; Signal; Viral envelope protein;
KW   Viral penetration into host cytoplasm; Virion.
FT   SIGNAL        1     30       Potential.
FT   CHAIN        31    278       Envelope glycoprotein L.
FT                                /FTId=PRO_0000038278.
FT   CARBOHYD     74     74       N-linked (GlcNAc...); by host
FT                                (Potential).
SQ   SEQUENCE   278 AA;  30913 MW;  9DD91A50BE0C25E5 CRC64;
     MCRRPDCGFS FSPGPVVLLW CCLLLPIVSS VAVSVAPTAA EKVPAECPEL TRRCLLGEVF
     QGDKYESWLR PLVNVTRRDG PLSQLIRYRP VTPEAANSVL LDDAFLDTLA LLYNNPDQLR
     ALLTLLSSDT APRWMTVMRG YSECGDGSPA VYTCVDDLCR GYDLTRLSYG RSIFTEHVLG
     FELVPPSLFN VVVAIRNEAT RTNRAVRLPV STAAAPEGIT LFYGLYNAVK EFCLRHQLDP
     PLLRHLDKYY AGLPPELKQT RVNLPAHSRY GPQAVDAR
//