ID GL_HCMVA Reviewed; 278 AA. AC P16832; Q7M6S9; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 2. DT 19-JAN-2010, entry version 52. DE RecName: Full=Envelope glycoprotein L; DE Short=gL; DE Flags: Precursor; GN Name=GL; Synonyms=UL115; OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5). OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Betaherpesvirinae; Cytomegalovirus. OX NCBI_TaxID=10360; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=90269039; PubMed=2161319; RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.; RT "Analysis of the protein-coding content of the sequence of human RT cytomegalovirus strain AD169."; RL Curr. Top. Microbiol. Immunol. 154:125-169(1990). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=22255414; PubMed=12368327; RX DOI=10.1128/JVI.76.21.10841-10848.2002; RA Rasmussen L., Geissler A., Cowan C., Chase A., Winters M.; RT "The genes encoding the gCIII complex of human cytomegalovirus exist RT in highly diverse combinations in clinical isolates."; RL J. Virol. 76:10841-10848(2002). RN [3] RP GENOME REANNOTATION. RC STRAIN=Isolate 650, and Isolate 813; RX MEDLINE=22421467; PubMed=12533697; DOI=10.1099/vir.0.18606-0; RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RT "The human cytomegalovirus genome revisited: comparison with the RT chimpanzee cytomegalovirus genome."; RL J. Gen. Virol. 84:17-28(2003). RN [4] RP ERRATUM. RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RL J. Gen. Virol. 84:1053-1053(2003). RN [5] RP IDENTIFICATION IN A COMPLEX WITH GO AND GH. RX PubMed=9733861; RA Huber M.T., Compton T.; RT "The human cytomegalovirus UL74 gene encodes the third component of RT the glycoprotein H-glycoprotein L-containing envelope complex."; RL J. Virol. 72:8191-8197(1998). RN [6] RP IDENTIFICATION. RX PubMed=15452216; DOI=10.1128/JVI.78.20.10960-10966.2004; RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RT "Identification of proteins in human cytomegalovirus (HCMV) particles: RT the HCMV proteome."; RL J. Virol. 78:10960-10966(2004). RN [7] RP ERRATUM. RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RL J. Virol. 78:13395-13395(2004). CC -!- FUNCTION: The heterodimer glycoprotein H-glycoprotein L is CC required for the fusion of viral and cellular membranes leading to CC virus entry into the host cell. Membrane fusion is mediated by the CC fusion machinery composed at least of gB and the heterodimer CC gH/gL. CC -!- SUBUNIT: Interacts with glycoprotein H (gH) (By similarity). CC -!- SUBCELLULAR LOCATION: Virion membrane; Peripheral membrane CC protein; Extracellular side (By similarity). Host cell membrane; CC Peripheral membrane protein; Extracellular side (By similarity). CC Note=gL is not anchored to the viral envelope, but associates with CC the extravirion surface through its binding to gH (By similarity). CC -!- SIMILARITY: Belongs to the herpesviridae glycoprotein L family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17403; CAA35317.1; ALT_INIT; Genomic_DNA. DR EMBL; AF530171; AAM96168.1; -; Genomic_DNA. DR EMBL; AF530172; AAM96169.1; -; Genomic_DNA. DR EMBL; AF530173; AAM96170.1; -; Genomic_DNA. DR EMBL; BK000394; DAA00105.1; -; Genomic_DNA. DR PIR; S09882; S09882. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0016032; P:viral reproduction; IEA:InterPro. DR InterPro; IPR002689; Cytomegalo_gL. DR Pfam; PF01801; Cytomega_gL; 1. PE 1: Evidence at protein level; KW Complete proteome; Envelope protein; Glycoprotein; Host cell membrane; KW Host membrane; Membrane; Signal; Virion. FT SIGNAL 1 30 Potential. FT CHAIN 31 278 Envelope glycoprotein L. FT /FTId=PRO_0000038278. FT CARBOHYD 74 74 N-linked (GlcNAc...); by host FT (Potential). SQ SEQUENCE 278 AA; 30913 MW; 9DD91A50BE0C25E5 CRC64; MCRRPDCGFS FSPGPVVLLW CCLLLPIVSS VAVSVAPTAA EKVPAECPEL TRRCLLGEVF QGDKYESWLR PLVNVTRRDG PLSQLIRYRP VTPEAANSVL LDDAFLDTLA LLYNNPDQLR ALLTLLSSDT APRWMTVMRG YSECGDGSPA VYTCVDDLCR GYDLTRLSYG RSIFTEHVLG FELVPPSLFN VVVAIRNEAT RTNRAVRLPV STAAAPEGIT LFYGLYNAVK EFCLRHQLDP PLLRHLDKYY AGLPPELKQT RVNLPAHSRY GPQAVDAR //