ID   GL_HCMVA                Reviewed;         278 AA.
AC   P16832; Q7M6S9;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   02-SEP-2008, entry version 46.
DE   RecName: Full=Glycoprotein L;
DE            Short=gL;
DE   Flags: Precursor;
GN   Name=GL; Synonyms=UL115;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=90269039; PubMed=2161319;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=22255414; PubMed=12368327;
RX   DOI=10.1128/JVI.76.21.10841-10848.2002;
RA   Rasmussen L., Geissler A., Cowan C., Chase A., Winters M.;
RT   "The genes encoding the gCIII complex of human cytomegalovirus exist
RT   in highly diverse combinations in clinical isolates.";
RL   J. Virol. 76:10841-10848(2002).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Isolate 650, and Isolate 813;
RX   MEDLINE=22421467; PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J.,
RA   Alcendor D.J., McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the
RT   chimpanzee cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [4]
RP   ERRATUM.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J.,
RA   Alcendor D.J., McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [5]
RP   IDENTIFICATION IN A COMPLEX WITH GO AND GH.
RX   PubMed=9733861;
RA   Huber M.T., Compton T.;
RT   "The human cytomegalovirus UL74 gene encodes the third component of
RT   the glycoprotein H-glycoprotein L-containing envelope complex.";
RL   J. Virol. 72:8191-8197(1998).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=15452216; DOI=10.1128/JVI.78.20.10960-10966.2004;
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RT   "Identification of proteins in human cytomegalovirus (HCMV) particles:
RT   the HCMV proteome.";
RL   J. Virol. 78:10960-10966(2004).
RN   [7]
RP   ERRATUM.
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RL   J. Virol. 78:13395-13395(2004).
CC   -!- FUNCTION: The complex glycoprotein H-glycoprotein L is important
CC       for infection and cell fusion. Also induces neutralizing and
CC       syncytia inhibiting antibodies.
CC   -!- SUBUNIT: Associates with the gL-gH-gO complex. The interaction
CC       with gH is necessary for the correct processing and cell surface
CC       expression of gH (By similarity).
CC   -!- SUBCELLULAR LOCATION: Virion membrane (Probable). Cell membrane
CC       (By similarity).
CC   -!- MISCELLANEOUS: Found in the virion.
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein L family.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X17403; CAA35317.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AF530171; AAM96168.1; -; Genomic_DNA.
DR   EMBL; AF530172; AAM96169.1; -; Genomic_DNA.
DR   EMBL; AF530173; AAM96170.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00105.1; -; Genomic_DNA.
DR   PIR; S09882; S09882.
DR   RefSeq; NP_783793.1; -.
DR   GeneID; 1487868; -.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002689; Cytomegalo_gL.
DR   Pfam; PF01801; Cytomega_gL; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Complete proteome; Envelope protein; Glycoprotein;
KW   Membrane; Signal; Virion.
FT   SIGNAL        1     30       Potential.
FT   CHAIN        31    278       Glycoprotein L.
FT                                /FTId=PRO_0000038278.
FT   CARBOHYD     74     74       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   278 AA;  30913 MW;  9DD91A50BE0C25E5 CRC64;
     MCRRPDCGFS FSPGPVVLLW CCLLLPIVSS VAVSVAPTAA EKVPAECPEL TRRCLLGEVF
     QGDKYESWLR PLVNVTRRDG PLSQLIRYRP VTPEAANSVL LDDAFLDTLA LLYNNPDQLR
     ALLTLLSSDT APRWMTVMRG YSECGDGSPA VYTCVDDLCR GYDLTRLSYG RSIFTEHVLG
     FELVPPSLFN VVVAIRNEAT RTNRAVRLPV STAAAPEGIT LFYGLYNAVK EFCLRHQLDP
     PLLRHLDKYY AGLPPELKQT RVNLPAHSRY GPQAVDAR
//