ID   VGLL_HCMVA     STANDARD;      PRT;   278 AA.
AC   P16832; Q7M6S9;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   30-MAY-2006, entry version 38.
DE   Glycoprotein L precursor.
GN   Name=GL; Synonyms=UL115;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesviridae;
OC   Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=90269039; PubMed=2161319;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=22255414; PubMed=12368327;
RX   DOI=10.1128/JVI.76.21.10841-10848.2002;
RA   Rasmussen L., Geissler A., Cowan C., Chase A., Winters M.;
RT   "The genes encoding the gCIII complex of human cytomegalovirus exist
RT   in highly diverse combinations in clinical isolates.";
RL   J. Virol. 76:10841-10848(2002).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Isolate 650, and Isolate 813;
RX   MEDLINE=22421467; PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J.,
RA   Alcendor D.J., McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the
RT   chimpanzee cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [4]
RP   ERRATUM.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J.,
RA   Alcendor D.J., McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=15452216; DOI=10.1128/JVI.78.20.10960-10966.2004;
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RT   "Identification of proteins in human cytomegalovirus (HCMV) particles:
RT   the HCMV proteome.";
RL   J. Virol. 78:10960-10966(2004).
RN   [6]
RP   ERRATUM.
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RL   J. Virol. 78:13395-13395(2004).
CC   -!- FUNCTION: The complex glycoprotein H-glycoprotein L is important
CC       for infection and cell fusion. Also induces neutralizing and
CC       syncytia inhibiting antibodies.
CC   -!- SUBUNIT: Interacts with glycoprotein H (gH). This association is
CC       necessary for the correct processing and cell surface expression
CC       of gH.
CC   -!- MISCELLANEOUS: Found in the virion.
CC   -!- SIMILARITY: Belongs to the herpesviruses glycoprotein L family.
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DR   EMBL; X17403; CAA35317.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AF530171; AAM96168.1; -; Genomic_DNA.
DR   EMBL; AF530172; AAM96169.1; -; Genomic_DNA.
DR   EMBL; AF530173; AAM96170.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00105.1; -; Genomic_DNA.
DR   PIR; S09882; S09882.
DR   InterPro; IPR002689; Cytomegalo_gL.
DR   Pfam; PF01801; Cytomega_gL; 1.
KW   Envelope protein; Glycoprotein; Signal; Virion protein.
FT   SIGNAL        1     30       Potential.
FT   CHAIN        31    278       Glycoprotein L.
FT                                /FTId=PRO_0000038278.
FT   CARBOHYD     74     74       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   278 AA;  30913 MW;  9DD91A50BE0C25E5 CRC64;
     MCRRPDCGFS FSPGPVVLLW CCLLLPIVSS VAVSVAPTAA EKVPAECPEL TRRCLLGEVF
     QGDKYESWLR PLVNVTRRDG PLSQLIRYRP VTPEAANSVL LDDAFLDTLA LLYNNPDQLR
     ALLTLLSSDT APRWMTVMRG YSECGDGSPA VYTCVDDLCR GYDLTRLSYG RSIFTEHVLG
     FELVPPSLFN VVVAIRNEAT RTNRAVRLPV STAAAPEGIT LFYGLYNAVK EFCLRHQLDP
     PLLRHLDKYY AGLPPELKQT RVNLPAHSRY GPQAVDAR
//