ID VGLL_HCMVA STANDARD; PRT; 278 AA. AC P16832; Q7M6S9; DT 01-AUG-1990 (Rel. 15, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE Glycoprotein L precursor. GN Name=GL; Synonyms=UL115; OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5). OC Viruses; dsDNA viruses, no RNA stage; Herpesviridae; OC Betaherpesvirinae; Cytomegalovirus. OX NCBI_TaxID=10360; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=90269039; PubMed=2161319; RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.; RT "Analysis of the protein-coding content of the sequence of human RT cytomegalovirus strain AD169."; RL Curr. Top. Microbiol. Immunol. 154:125-169(1990). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=22255414; PubMed=12368327; RX DOI=10.1128/JVI.76.21.10841-10848.2002; RA Rasmussen L., Geissler A., Cowan C., Chase A., Winters M.; RT "The genes encoding the gCIII complex of human cytomegalovirus exist RT in highly diverse combinations in clinical isolates."; RL J. Virol. 76:10841-10848(2002). RN [3] RP GENOME REANNOTATION. RC STRAIN=Isolate 650, and Isolate 813; RX MEDLINE=22421467; PubMed=12533697; DOI=10.1099/vir.0.18606-0; RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RT "The human cytomegalovirus genome revisited: comparison with the RT chimpanzee cytomegalovirus genome."; RL J. Gen. Virol. 84:17-28(2003). RN [4] RP ERRATUM. RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RL J. Gen. Virol. 84:1053-1053(2003). RN [5] RP IDENTIFICATION. RX PubMed=15452216; DOI=10.1128/JVI.78.20.10960-10966.2004; RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RT "Identification of proteins in human cytomegalovirus (HCMV) particles: RT the HCMV proteome."; RL J. Virol. 78:10960-10966(2004). RN [6] RP ERRATUM. RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RL J. Virol. 78:13395-13395(2004). CC -!- FUNCTION: The complex glycoprotein H-glycoprotein L is important CC for infection and cell fusion. Also induces neutralizing and CC syncytia inhibiting antibodies. CC -!- SUBUNIT: Interacts with glycoprotein H (gH). This association is CC necessary for the correct processing and cell surface expression CC of gH. CC -!- MISCELLANEOUS: Found in the virion. CC -!- SIMILARITY: Belongs to the herpesviruses glycoprotein L family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17403; CAA35317.1; ALT_INIT; Genomic_DNA. DR EMBL; AF530171; AAM96168.1; -; Genomic_DNA. DR EMBL; AF530172; AAM96169.1; -; Genomic_DNA. DR EMBL; AF530173; AAM96170.1; -; Genomic_DNA. DR EMBL; BK000394; DAA00105.1; -; Genomic_DNA. DR PIR; S09882; S09882. DR InterPro; IPR002689; Cytomegalo_gL. DR Pfam; PF01801; Cytomega_gL; 1. KW Envelope protein; Glycoprotein; Signal; Structural protein. FT SIGNAL 1 30 Potential. FT CHAIN 31 278 Glycoprotein L. FT /FTId=PRO_0000038278. FT CARBOHYD 74 74 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 278 AA; 30913 MW; 9DD91A50BE0C25E5 CRC64; MCRRPDCGFS FSPGPVVLLW CCLLLPIVSS VAVSVAPTAA EKVPAECPEL TRRCLLGEVF QGDKYESWLR PLVNVTRRDG PLSQLIRYRP VTPEAANSVL LDDAFLDTLA LLYNNPDQLR ALLTLLSSDT APRWMTVMRG YSECGDGSPA VYTCVDDLCR GYDLTRLSYG RSIFTEHVLG FELVPPSLFN VVVAIRNEAT RTNRAVRLPV STAAAPEGIT LFYGLYNAVK EFCLRHQLDP PLLRHLDKYY AGLPPELKQT RVNLPAHSRY GPQAVDAR //