ID PORTL_HCMVA Reviewed; 697 AA. AC P16735; Q7M6T5; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 16-DEC-2008, sequence version 2. DT 02-OCT-2024, entry version 89. DE RecName: Full=Portal protein {ECO:0000255|HAMAP-Rule:MF_04012}; GN Name=UL104; OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5). OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; OC Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus; OC Cytomegalovirus humanbeta5; Human cytomegalovirus. OX NCBI_TaxID=10360; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6; RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.; RT "Analysis of the protein-coding content of the sequence of human RT cytomegalovirus strain AD169."; RL Curr. Top. Microbiol. Immunol. 154:125-169(1990). RN [2] RP GENOME REANNOTATION. RX PubMed=12533697; DOI=10.1099/vir.0.18606-0; RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., RA McGeoch D.J., Hayward G.S.; RT "The human cytomegalovirus genome revisited: comparison with the chimpanzee RT cytomegalovirus genome."; RL J. Gen. Virol. 84:17-28(2003). RN [3] RP ERRATUM OF PUBMED:12533697. RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., RA McGeoch D.J., Hayward G.S.; RL J. Gen. Virol. 84:1053-1053(2003). RN [4] RP IDENTIFICATION. RX PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004; RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RT "Identification of proteins in human cytomegalovirus (HCMV) particles: the RT HCMV proteome."; RL J. Virol. 78:10960-10966(2004). RN [5] RP ERRATUM OF PUBMED:15452216. RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RL J. Virol. 78:13395-13395(2004). RN [6] RP SEQUENCE REVISION TO 157. RA Davison A.J.; RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Forms a portal in the viral capsid through which viral DNA is CC translocated during DNA packaging. Assembles as a dodecamer at a single CC fivefold axe of the T=16 icosahedric capsid. Binds to the molecular CC motor that translocates the viral DNA, termed terminase. CC {ECO:0000255|HAMAP-Rule:MF_04012}. CC -!- SUBUNIT: Homododecamerizes. Interacts with terminase subunits TRM1 and CC TRM3. {ECO:0000255|HAMAP-Rule:MF_04012}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04012}. Host CC nucleus {ECO:0000255|HAMAP-Rule:MF_04012}. CC -!- SIMILARITY: Belongs to the herpesviridae portal protein family. CC {ECO:0000255|HAMAP-Rule:MF_04012}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17403; CAA35341.1; -; Genomic_DNA. DR EMBL; BK000394; DAA00099.2; -; Genomic_DNA. DR PIR; S09870; QQBEK3. DR PDB; 7ET2; EM; 4.20 A; A/B/C/D/E/F/G/H/I/J/K/L=1-697. DR PDB; 7ETM; EM; 5.90 A; A/B/C/D/E/F/G/H/I/J/K/L=1-697. DR PDB; 8HEU; EM; 4.60 A; A/B/C/D/E/F/G/H/I/J/K/L=1-697. DR PDB; 8HEV; EM; 4.20 A; A/B/C/G/H/I/J/K/L/M/U/V=1-697. DR PDBsum; 7ET2; -. DR PDBsum; 7ETM; -. DR PDBsum; 8HEU; -. DR PDBsum; 8HEV; -. DR EMDB; EMD-34693; -. DR SMR; P16735; -. DR Proteomes; UP000008991; Segment. DR Proteomes; UP000008992; Segment. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW. DR GO; GO:0051276; P:chromosome organization; IEA:InterPro. DR HAMAP; MF_04012; HSV_PORTL; 1. DR InterPro; IPR002660; Herpes_Portal. DR Pfam; PF01763; Herpes_UL6; 1. PE 1: Evidence at protein level; KW 3D-structure; Host nucleus; Reference proteome; Viral genome packaging; KW Viral release from host cell; Virion. FT CHAIN 1..697 FT /note="Portal protein" FT /id="PRO_0000115913" FT REGION 633..697 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 661..685 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 697 AA; 78521 MW; 4A86400FDC16AAFA CRC64; MERNHWNEKS SGAKRSRERD LTLSTIRSIL AADERLRIKA SSYLGVGRGV DDEAVIDIFP TGQTMSFLRL LHGFLGTCRG QSMHQVLRDP CVLRKQLLYG VCKTLFDTIT VRRVAEEWKL HAALFPYRAL DEEDLEQYLL VWSASLRQSV QTGVLGALRD ILYQYADNDD YGLYVDWCVT VGLVPLLDVK TKPSEAAERA QFVRAAVQRA TETHPLAQDL LQANLALLLQ VAERLGAVRV ANAPEVRVFK KVRSERLEAQ LRGKHIRLYV AAEPLAYERD KLLFTTPVAH LHEEILRYDG LCRHQKICQL LNTFPVKVVT ASRHELNCKK LVEMMEQHDR GSDAKKSIMK FLLNVSDSKS RIGIEDSVES FLQDLTPSLV DQNRLLPARG PGGPGVVGPG GAVVGGPAGH VGLLPPPPGP AAPERDIRDL FKKQVIKCLE EQIQSQVDEI QDLRTLNQTW ENRVRELRDL LTRYASRRED SMSLGARDAE LYHLPVLEAV RKARDAAPFR PLAVEDNRLV ANSFFSQFVP GTESLERFLT QLWENEYFRT FRLRRLVTHQ GAEEAIVYSN YTVERVTLPY LCHILALGTL DPVPEAYLQL SFGEIVAAAY DDSKFCRYVE LICSREKARR RQMSREAAGG VPERGTASSG GPGTLERSAP RRLITADEER RGPERVGRFR NGGPDDPRRA GGPYGFH //