ID PORTL_HCMVA Reviewed; 697 AA. AC P16735; Q7M6T5; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 16-DEC-2008, sequence version 2. DT 10-MAY-2017, entry version 69. DE RecName: Full=Portal protein {ECO:0000255|HAMAP-Rule:MF_04012}; GN Name=UL104; OS Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5). OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Betaherpesvirinae; Cytomegalovirus. OX NCBI_TaxID=10360; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=2161319; RA Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., RA Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., RA Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.; RT "Analysis of the protein-coding content of the sequence of human RT cytomegalovirus strain AD169."; RL Curr. Top. Microbiol. Immunol. 154:125-169(1990). RN [2] RP GENOME REANNOTATION. RX PubMed=12533697; DOI=10.1099/vir.0.18606-0; RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RT "The human cytomegalovirus genome revisited: comparison with the RT chimpanzee cytomegalovirus genome."; RL J. Gen. Virol. 84:17-28(2003). RN [3] RP ERRATUM. RA Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., RA Alcendor D.J., McGeoch D.J., Hayward G.S.; RL J. Gen. Virol. 84:1053-1053(2003). RN [4] RP IDENTIFICATION. RX PubMed=15452216; DOI=10.1128/JVI.78.20.10960-10966.2004; RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RT "Identification of proteins in human cytomegalovirus (HCMV) particles: RT the HCMV proteome."; RL J. Virol. 78:10960-10966(2004). RN [5] RP ERRATUM. RA Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., RA Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., RA Shenk T., Smith R.D., Nelson J.A.; RL J. Virol. 78:13395-13395(2004). RN [6] RP SEQUENCE REVISION TO 157. RA Davison A.J.; RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Forms a portal in the viral capsid through which viral CC DNA is translocated during DNA packaging. Assembles as a dodecamer CC at a single fivefold axe of the T=16 icosahedric capsid. Binds to CC the molecular motor that translocates the viral DNA, termed CC terminase. {ECO:0000255|HAMAP-Rule:MF_04012}. CC -!- SUBUNIT: Homododecamerizes. Interacts with terminase subunits TRM1 CC and TRM3. {ECO:0000255|HAMAP-Rule:MF_04012}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04012}. CC Host nucleus {ECO:0000255|HAMAP-Rule:MF_04012}. CC -!- SIMILARITY: Belongs to the herpesviridae portal protein family. CC {ECO:0000255|HAMAP-Rule:MF_04012}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17403; CAA35341.1; -; Genomic_DNA. DR EMBL; BK000394; DAA00099.2; -; Genomic_DNA. DR PIR; S09870; QQBEK3. DR ProteinModelPortal; P16735; -. DR SMR; P16735; -. DR PRIDE; P16735; -. DR OrthoDB; VOG0900002I; -. DR Proteomes; UP000008991; Genome. DR Proteomes; UP000008992; Genome. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0006323; P:DNA packaging; IEA:InterPro. DR GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-KW. DR HAMAP; MF_04012; HSV_PORTL; 1. DR InterPro; IPR002660; Herpes_Portal. DR Pfam; PF01763; Herpes_UL6; 1. PE 3: Inferred from homology; KW Complete proteome; Host nucleus; Reference proteome; KW Viral genome packaging; Virion; Virus exit from host cell. FT CHAIN 1 697 Portal protein. FT /FTId=PRO_0000115913. SQ SEQUENCE 697 AA; 78521 MW; 4A86400FDC16AAFA CRC64; MERNHWNEKS SGAKRSRERD LTLSTIRSIL AADERLRIKA SSYLGVGRGV DDEAVIDIFP TGQTMSFLRL LHGFLGTCRG QSMHQVLRDP CVLRKQLLYG VCKTLFDTIT VRRVAEEWKL HAALFPYRAL DEEDLEQYLL VWSASLRQSV QTGVLGALRD ILYQYADNDD YGLYVDWCVT VGLVPLLDVK TKPSEAAERA QFVRAAVQRA TETHPLAQDL LQANLALLLQ VAERLGAVRV ANAPEVRVFK KVRSERLEAQ LRGKHIRLYV AAEPLAYERD KLLFTTPVAH LHEEILRYDG LCRHQKICQL LNTFPVKVVT ASRHELNCKK LVEMMEQHDR GSDAKKSIMK FLLNVSDSKS RIGIEDSVES FLQDLTPSLV DQNRLLPARG PGGPGVVGPG GAVVGGPAGH VGLLPPPPGP AAPERDIRDL FKKQVIKCLE EQIQSQVDEI QDLRTLNQTW ENRVRELRDL LTRYASRRED SMSLGARDAE LYHLPVLEAV RKARDAAPFR PLAVEDNRLV ANSFFSQFVP GTESLERFLT QLWENEYFRT FRLRRLVTHQ GAEEAIVYSN YTVERVTLPY LCHILALGTL DPVPEAYLQL SFGEIVAAAY DDSKFCRYVE LICSREKARR RQMSREAAGG VPERGTASSG GPGTLERSAP RRLITADEER RGPERVGRFR NGGPDDPRRA GGPYGFH //