ID KITH_SHEVK Reviewed; 177 AA. AC P16600; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1990, sequence version 1. DT 05-JUN-2019, entry version 63. DE RecName: Full=Thymidine kinase; DE EC=2.7.1.21; GN Name=TK; OS Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1)). OC Viruses; Poxviridae; Chordopoxvirinae; Capripoxvirus. OX NCBI_TaxID=10269; OH NCBI_TaxID=9940; Ovis aries (Sheep). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=2732700; DOI=10.1099/0022-1317-70-3-525; RA Gershon P.D., Black D.N.; RT "The nucleotide sequence around the capripoxvirus thymidine kinase RT gene reveals a gene shared specifically with leporipoxvirus."; RL J. Gen. Virol. 70:525-533(1989). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + thymidine = ADP + dTMP + H(+); CC Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; CC EC=2.7.1.21; CC -!- SIMILARITY: Belongs to the thymidine kinase family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D00423; BAA00324.1; -; Genomic_DNA. DR PIR; B31813; KIVZCP. DR SMR; P16600; -. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC. DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR001267; Thymidine_kinase. DR InterPro; IPR020633; Thymidine_kinase_CS. DR PANTHER; PTHR11441; PTHR11441; 1. DR Pfam; PF00265; TK; 1. DR PIRSF; PIRSF035805; TK_cell; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS00603; TK_CELLULAR_TYPE; 1. PE 3: Inferred from homology; KW ATP-binding; DNA synthesis; Kinase; Metal-binding; Nucleotide-binding; KW Transferase; Zinc. FT CHAIN 1 177 Thymidine kinase. FT /FTId=PRO_0000174929. FT NP_BIND 11 18 ATP. {ECO:0000250}. FT REGION 157 161 Substrate binding. {ECO:0000250}. FT ACT_SITE 83 83 Proton acceptor. {ECO:0000255}. FT METAL 138 138 Zinc. {ECO:0000250}. FT METAL 141 141 Zinc. {ECO:0000250}. FT METAL 170 170 Zinc. {ECO:0000250}. FT METAL 173 173 Zinc. {ECO:0000250}. FT BINDING 113 113 Substrate; via amide nitrogen. FT {ECO:0000250}. SQ SEQUENCE 177 AA; 20447 MW; 093E53E555F8E2C8 CRC64; MDYGYIHLII GPMFSGKSTE LIRIVKRYQI AQYKCCVVKY LKDIRYGNSV YTHDNNHVSA ISTTLLYDVV DKIMNFDIIG IDEGQFFKDI VSFSENMANM GKIIIIAALD STFQRKEFND ILKLIPLSEK VTKLNAVCME CYKDAAFSKR ITKEKEIELI GGKEKYKSVC RKCYFLE //