ID KITH_SHEVK Reviewed; 177 AA. AC P16600; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1990, sequence version 1. DT 19-FEB-2014, entry version 50. DE RecName: Full=Thymidine kinase; DE EC=2.7.1.21; GN Name=TK; OS Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1)). OC Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; OC Capripoxvirus. OX NCBI_TaxID=10269; OH NCBI_TaxID=9940; Ovis aries (Sheep). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=2732700; RA Gershon P.D., Black D.N.; RT "The nucleotide sequence around the capripoxvirus thymidine kinase RT gene reveals a gene shared specifically with leporipoxvirus."; RL J. Gen. Virol. 70:525-533(1989). CC -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'- CC phosphate. CC -!- SIMILARITY: Belongs to the thymidine kinase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D00423; BAA00324.1; -; Genomic_DNA. DR PIR; B31813; KIVZCP. DR ProteinModelPortal; P16600; -. DR SMR; P16600; 4-175. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC. DR GO; GO:0009157; P:deoxyribonucleoside monophosphate biosynthetic process; IEA:GOC. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. DR GO; GO:0009165; P:nucleotide biosynthetic process; IEA:GOC. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR001267; Thymidine_kinase. DR InterPro; IPR020633; Thymidine_kinase_CS. DR PANTHER; PTHR11441; PTHR11441; 1. DR Pfam; PF00265; TK; 1. DR PIRSF; PIRSF035805; TK_cell; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR PROSITE; PS00603; TK_CELLULAR_TYPE; 1. PE 3: Inferred from homology; KW ATP-binding; DNA synthesis; Kinase; Metal-binding; Nucleotide-binding; KW Transferase; Zinc. FT CHAIN 1 177 Thymidine kinase. FT /FTId=PRO_0000174929. FT NP_BIND 11 18 ATP (By similarity). FT REGION 157 161 Substrate binding (By similarity). FT ACT_SITE 83 83 Proton acceptor (Potential). FT METAL 138 138 Zinc (By similarity). FT METAL 141 141 Zinc (By similarity). FT METAL 170 170 Zinc (By similarity). FT METAL 173 173 Zinc (By similarity). FT BINDING 113 113 Substrate; via amide nitrogen (By FT similarity). SQ SEQUENCE 177 AA; 20447 MW; 093E53E555F8E2C8 CRC64; MDYGYIHLII GPMFSGKSTE LIRIVKRYQI AQYKCCVVKY LKDIRYGNSV YTHDNNHVSA ISTTLLYDVV DKIMNFDIIG IDEGQFFKDI VSFSENMANM GKIIIIAALD STFQRKEFND ILKLIPLSEK VTKLNAVCME CYKDAAFSKR ITKEKEIELI GGKEKYKSVC RKCYFLE //