ID KITH_SHEVK Reviewed; 177 AA. AC P16600; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1990, sequence version 1. DT 19-JAN-2010, entry version 40. DE RecName: Full=Thymidine kinase; DE EC=2.7.1.21; GN Name=TK; OS Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1)). OC Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; OC Capripoxvirus. OX NCBI_TaxID=10269; OH NCBI_TaxID=9940; Ovis aries (Sheep). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=89279233; PubMed=2732700; RA Gershon P.D., Black D.N.; RT "The nucleotide sequence around the capripoxvirus thymidine kinase RT gene reveals a gene shared specifically with leporipoxvirus."; RL J. Gen. Virol. 70:525-533(1989). CC -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'- CC phosphate. CC -!- SIMILARITY: Belongs to the thymidine kinase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D00423; BAA00324.1; -; Genomic_DNA. DR PIR; B31813; KIVZCP. DR SMR; P16600; 4-175. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004797; F:thymidine kinase activity; IEA:EC. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. DR InterPro; IPR001267; Thymidine_kinase. DR InterPro; IPR020633; Thymidine_kinase_CS. DR PANTHER; PTHR11441; TK_cell; 1. DR Pfam; PF00265; TK; 1. DR PIRSF; PIRSF035805; TK_cell; 1. DR PROSITE; PS00603; TK_CELLULAR_TYPE; 1. PE 3: Inferred from homology; KW ATP-binding; DNA synthesis; Kinase; Nucleotide-binding; Transferase. FT CHAIN 1 177 Thymidine kinase. FT /FTId=PRO_0000174929. FT NP_BIND 11 18 ATP (Probable). SQ SEQUENCE 177 AA; 20447 MW; 093E53E555F8E2C8 CRC64; MDYGYIHLII GPMFSGKSTE LIRIVKRYQI AQYKCCVVKY LKDIRYGNSV YTHDNNHVSA ISTTLLYDVV DKIMNFDIIG IDEGQFFKDI VSFSENMANM GKIIIIAALD STFQRKEFND ILKLIPLSEK VTKLNAVCME CYKDAAFSKR ITKEKEIELI GGKEKYKSVC RKCYFLE //