ID FMOH$PIG STANDARD; PRT; 532 AA. AC P16549; DT 01-AUG-1990 (REL. 15, CREATED) DT 01-AUG-1990 (REL. 15, LAST SEQUENCE UPDATE) DT 01-NOV-1991 (REL. 20, LAST ANNOTATION UPDATE) DE DIMETHYLANILINE MONOOXYGENASE (N-OXIDE FORMING) (EC 1.14.13.8) DE (HEPATIC FLAVIN-CONTAINING MONOOXYGENASE) (FMO) (DIMETHYLANILINE DE OXIDASE). OS SUS SCROFA (PIG). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; ARTIODACTYLA. RN [1] RP SEQUENCE FROM N.A., AND SEQUENCE OF 309-318, 137-151. RC TISSUE=LIVER; RC MEDLINE=90212556; RA GASSER R., TYNES R.E., LAWTON M.P., KORSMEYER K.K., ZIEGLER D.M., RA PHILPOT R.M.; RL BIOCHEMISTRY 29:119-124(1990). CC -!- FUNCTION: THIS PROTEIN IS INVOLVED IN THE METABOLISM OF XENO- CC BIOTICS BY OXIDATION OF VARIOUS SUBSTRATES. CC -!- CATALYTIC ACTIVITY: N,N-DIMETHYLANILINE + NADPH + O(2) = CC N,N-DIMETHYLANILINE N-OXIDE + NADP(+) + H(2)O. CC -!- SUBCELLULAR LOCATION: MICROSOME. CC -!- COFACTOR: FAD FLAVOPROTEIN. CC -!- TISSUE SPECIFICITY: LIVER. CC -!- SIMILARITY: 87% IDENTICAL TO THE RABBIT LIVER FMO. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M32031; SSFMOAA. DR PIR; A33768; A33768. KW OXIDOREDUCTASE; MONOOXYGENASE; NADP; FLAVOPROTEIN; FAD; MICROSOME; KW TRANSMEMBRANE. FT NP_BIND 5 15 FAD (PUTATIVE). FT NP_BIND 186 201 NADP (PUTATIVE). SQ SEQUENCE 532 AA; 59952 MW; 1572367 CN; MAKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSDDLGGL WRFTEHVEEG RASLYKSVVS NSCKEMSCYP DFPFPEDYPN YVPNSHFLEY LRMYANQFNL LKCIQFKTKV CSVTKHEDFN TTGQWDVVTL CEGKQESAVF DAVMVCTGFL TNPYLPLDSF PGINTFKGQY FHSRQYKHPD IFKDKSVLVV GMGNSGTDIA VEASHLAKKV FLSTTGGAWV ISRVFDSGYP WDMVFMTRFQ NMFRNSLPTP IVNWLIAKKM NSWFNHANYG LIPEDRIQLR EPVLNDELPG RIITGKVLIK PSIKEVKENS VVFNSSPEEE PIDIIVFATG YTFAFPFLDE SVVKVEDGQA SLYKYIFPAH LQKPTLAVIG LIKPLGSLLP TGDTQARWAV RVLKGVNKLP PSSVMIQEVN TRKENKPSGF GLCYCKALQS DYIAYIDELL TYIDAKPNMF SLLLTDPHLA LTIFFGPCTP YQFRLTGPGK WEGARNAIMT QWDRTFKVTK TRIVKESPSP FASLLKLFSF LALLVAIFQI FL //