ID UTXA_CLODI Reviewed; 166 AA. AC P16153; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1996, sequence version 2. DT 12-AUG-2020, entry version 83. DE RecName: Full=Protein UtxA; GN Name=utxA; Synonyms=tcdE; OS Clostridioides difficile (Peptoclostridium difficile). OC Bacteria; Firmicutes; Clostridia; Clostridiales; Peptostreptococcaceae; OC Clostridioides. OX NCBI_TaxID=1496; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 4325 / VPI 10463; RX PubMed=1603068; DOI=10.1007/bf00587587; RA von Eichel-Streiber C., Laufenberg-Feldmann R., Sartingen S., Schulze J., RA Sauerborn M.; RT "Comparative sequence analysis of the Clostridium difficile toxins A and RT B."; RL Mol. Gen. Genet. 233:260-268(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 4325 / VPI 10463; RX PubMed=2105276; RA Dove C.H., Wang S.-Z., Price S.B., Phelps C.J., Lyerly D.M., Wilkins T.D., RA Johnson J.L.; RT "Molecular characterization of the Clostridium difficile toxin A gene."; RL Infect. Immun. 58:480-488(1990). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 4325 / VPI 10463; RA von Eichel-Streiber C.; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-166. RC STRAIN=ATCC 4325 / VPI 10463; RX PubMed=2109310; DOI=10.1093/nar/18.6.1629; RA Sauerborn M., von Eichel-Streiber C.; RT "Nucleotide sequence of Clostridium difficile toxin A."; RL Nucleic Acids Res. 18:1629-1630(1990). CC -!- FUNCTION: May be involved in the regulation and/or secretion of toxins CC A and B. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative initiation; Named isoforms=2; CC Name=Long; CC IsoId=P16153-1; Sequence=Displayed; CC Name=Short; CC IsoId=P16153-2; Sequence=VSP_018824; CC -!- SEQUENCE CAUTION: CC Sequence=AAA83533.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC Sequence=CAA36093.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X60984; CAA43300.1; -; Genomic_DNA. DR EMBL; X60984; CAA43301.1; -; Genomic_DNA. DR EMBL; M30308; AAA83532.1; -; Genomic_DNA. DR EMBL; M30308; AAA83533.1; ALT_INIT; Genomic_DNA. DR EMBL; X92982; CAA63563.1; -; Genomic_DNA. DR EMBL; X51797; CAA36093.1; ALT_INIT; Genomic_DNA. DR PIR; B37052; B37052. DR RefSeq; WP_003434540.1; NZ_VINH01000002.1. [P16153-1] DR RefSeq; WP_018112585.1; NZ_BIWI01000430.1. DR TCDB; 1.E.19.3.1; the clostridium difficile tcde holin (tcde holin) family. DR GeneID; 31352217; -. DR GO; GO:0034291; F:canonical holin activity; IDA:CACAO. DR GO; GO:1901998; P:toxin transport; IMP:CACAO. DR InterPro; IPR006480; Phage_holin_4_1. DR Pfam; PF05105; Phage_holin_4_1; 1. DR TIGRFAMs; TIGR01593; holin_tox_secr; 1. PE 4: Predicted; KW Alternative initiation. FT CHAIN 1..166 FT /note="Protein UtxA" FT /id="PRO_0000022643" FT VAR_SEQ 1..26 FT /note="Missing (in isoform Short)" FT /evidence="ECO:0000305" FT /id="VSP_018824" SQ SEQUENCE 166 AA; 18800 MW; 1671FAE1884C7EE2 CRC64; MHSSSPFYIS NGNKIFFYIN LGGVMNMTIS FLSEHIFIKL VILTISFDTL LGCLSAIKSR KFNSSFGIDG GIRKVAMIAC IFFLSVVDIL TKFNFLFMLP QDCINFLRLK HLGISEFFSI LFILYESVSI LKNMCLCGLP VPKRLKEKIA ILLDAMTDEM NAKDEK //