ID RPA1_HALMO STANDARD; PRT; 349 AA. AC P15349; DT 01-APR-1990 (Rel. 14, Created) DT 01-APR-1990 (Rel. 14, Last sequence update) DT 01-FEB-1996 (Rel. 33, Last annotation update) DE DNA-DIRECTED RNA POLYMERASE SUBUNIT A' (EC 2.7.7.6) (FRAGMENT). GN RPOA1. OS Halococcus morrhuae. OC Archaea; Euryarchaeota; Halobacteriales; Halobacteriaceae; Halococcus. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=ATCC 17082; RX MEDLINE; 89199633. RA LEFFERS H., GROPP F., LOTTSPEICH F., ZILLIG W., GARRETT R.A.; RT "Sequence, organization, transcription and evolution of RNA RT polymerase subunit genes from the archaebacterial extreme halophiles RT Halobacterium halobium and Halococcus morrhuae."; RL J. Mol. Biol. 206:1-17(1989). CC -!- FUNCTION: DNA-DEPENDENT RNA POLYMERASE CATALYZES THE TRANSCRIPTION CC OF DNA INTO RNA USING THE FOUR RIBONUCLEOSIDE TRIPHOSPHATES AS CC SUBSTRATES. CC -!- CATALYTIC ACTIVITY: N NUCLEOSIDE TRIPHOSPHATE = N PYROPHOSPHATE + CC RNA(N). CC -!- COFACTOR: ZINC. CC -!- SUBUNIT: THIS RNA POLYMERASE IS COMPOSED OF 5 LARGE SUBUNITS: CC A',A",B',B" AND EPSILON, PRESENT IN STOICHIOMETRIC AMOUNTS, AND CC 3 SMALL ONES, E, F AND G, PRESENT IN SUB-STOICHIOMETRIC AMOUNTS. CC -!- SIMILARITY: THE COMBINED A'+A" SUBUNITS CORRESPOND TO THE A CC SUBUNITS OF EUKARYOTIC RNA POLYMERASES I, II AND III AND TO THE CC EUBACTERIAL BETA' SUBUNIT. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X57145; CAA40431.1; -. DR PIR; S03575; S03575. DR PFAM; PF00623; RNA_pol_A; 1. KW Transferase; DNA-directed RNA polymerase; Transcription; Zinc. FT NON_TER 1 1 FT CONFLICT 336 339 MISSING (IN CAA40431). SQ SEQUENCE 349 AA; 38074 MW; 98B94F45 CRC32; EFTSSTGDTV MIDEGALVEG TIDEDAVGAF GGEIVDTIVK QYGETRARVF INEVASLAMR AIMHFGFSIG IDDESISDAA EAQIDESMDN AYERVQELID TYENDDLESL PGRTVDETLE MKIMQTLGKA RDSAGDIADE HFDDDNPAVI MAESGARGSM LNLTQMAACV GQQAVRGERI NRGYEGRTLS HFKPGDLSAE AHGFVEDSYR SGLTPREFFF HAMGGREGLV DTAVRTSKSG YLQRRLINAL SELETQYDGT VRDTSDNIVQ FEFGEDNTSP VKVSSSDDNE IDVDEIADRV LAAEFEDEGE EFAGEQATNL SESADDRMDR DRPSSHGAAP IDVPEVGDD //