ID RPOA$HALMO STANDARD; PRT; 349 AA. AC P15349; DT 01-APR-1990 (REL. 14, CREATED) DT 01-APR-1990 (REL. 14, LAST SEQUENCE UPDATE) DT 01-APR-1990 (REL. 14, LAST ANNOTATION UPDATE) DE DNA-DIRECTED RNA POLYMERASE SUBUNIT A (EC 2.7.7.6) (FRAGMENT). OS HALOCOCCUS MORRHUAE. OC PROKARYOTA; ARCHAEBACTERIA; EXTREME HALOPHILES. RN [1] (STRAIN ATCC 17082, SEQUENCE FROM N.A.) RA LEFFERS H., GROPP F., LOTTSPEICH F., ZILLIG W., GARRETT R.A.; RL J. MOL. BIOL. 206:1-17(1989). CC -!- FUNCTION: DNA-DEPENDENT RNA POLYMERASE CATALYZES THE TRANSCRIPTION CC OF DNA INTO RNA USING THE FOUR RIBONUCLEOSIDE TRIPHOSPHATES AS CC SUBSTRATES. CC -!- CATALYTIC ACTIVITY: N NUCLEOSIDE TRIPHOSPHATE = N PYROPHOSPHATE + CC RNA(N). CC -!- COFACTOR: ZINC. CC -!- SUBUNIT: THIS RNA POLYMERASE IS COMPOSED OF 5 LARGE SUBUNITS: CC A, B', B'', C AND EPSILON, PRESENT IN STOICHIOMETRIC AMOUNTS, AND CC 3 SMALL ONES, E, F AND G, PRESENT IN SUB-STOICHIOMETRIC AMOUNTS. CC -!- SIMILARITY: THE COMBINED A+C SUBUNITS CORRESPOND TO THE A SUBUNITS CC OF EUKARYOTIC RNA POLYMERASES I, II AND III AND TO THE EUBACTERIAL CC BETA' SUBUNIT. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; S03575; S03575. KW TRANSCRIPTION; DNA-DIRECTED RNA POLYMERASE; ZINC. FT NON_TER 1 1 SQ SEQUENCE 349 AA; 38074 MW; 557054 CN; EFTSSTGDTV MIDEGALVEG TIDEDAVGAF GGEIVDTIVK QYGETRARVF INEVASLAMR AIMHFGFSIG IDDESISDAA EAQIDESMDN AYERVQELID TYENDDLESL PGRTVDETLE MKIMQTLGKA RDSAGDIADE HFDDDNPAVI MAESGARGSM LNLTQMAACV GQQAVRGERI NRGYEGRTLS HFKPGDLSAE AHGFVEDSYR SGLTPREFFF HAMGGREGLV DTAVRTSKSG YLQRRLINAL SELETQYDGT VRDTSDNIVQ FEFGEDNTSP VKVSSSDDNE IDVDEIADRV LAAEFEDEGE EFAGEQATNL SESADDRMDR DRPSSHGAAP IDVPEVGDD //