ID SC23_YEAST STANDARD; PRT; 768 AA. AC P15303; DT 01-APR-1990 (Rel. 14, Created) DT 01-APR-1990 (Rel. 14, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE PROTEIN TRANSPORT PROTEIN SEC23. GN SEC23 OR YPR181C OR P9705.14. OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=MBY8-20C; RX MEDLINE=89356640; PubMed=2670558; RA Hicke L., Schekman R.; RT "Yeast Sec23p acts in the cytoplasm to promote protein transport from RT the endoplasmic reticulum to the Golgi complex in vivo and in RT vitro."; RL EMBO J. 8:1677-1684(1989). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=S288C / AB972; RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., RA Favello A., Fulton L., Gattung S., Greco T., Kirsten J., RA Kucaba T., Hallsworth K., Hawkins J., Hillier L., Jier M., RA Johnson D., Johnston L., Langston Y., Latreille P., Le T., RA Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., RA Rifken L., Riles L., Taich A., Trevaskis E., Vignati D., RA Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R.; RL Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: COMPONENT OF THE COPII COAT, THAT COVERS ER-DERIVED CC VESICLES INVOLVED IN TRANSPORT FROM THE ENDOPLASMIC RETICULUM TO CC THE GOLGI APPARATUS. COPII IS COMPOSED OF AT LEAST FIVE PROTEINS: CC THE SEC23/24 COMPLEX, THE SEC13/31 COMPLEX, AND THE PROTEIN SAR1. CC ACTS IN THE CYTOPLASM TO PROMOTE THE TRANSPORT OF SECRETORY, CC PLASMA MEMBRANE, AND VACUOLAR PROTEINS FROM THE ENDOPLASMIC CC RETICULUM TO THE GOLGI COMPLEX. INTERACTS WITH PROTEIN SEC16. CC -!- SUBCELLULAR LOCATION: CYTOPLASMIC. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X15474; CAA33501.1; -. DR EMBL; U25842; AAB68114.1; -. DR PIR; S05742; BVBY23. DR SGD; S0006385; SEC23. KW Transport; Protein transport; Golgi stack; Endoplasmic reticulum. SQ SEQUENCE 768 AA; 85384 MW; 69811913848265FB CRC64; MDFETNEDIN GVRFTWNVFP STRSDANSNV VPVGCLYTPL KEYDELNVAP YNPVVCSGPH CKSILNPYCV IDPRNSSWSC PICNSRNHLP PQYTNLSQEN MPLELQSTTI EYITNKPVTV PPIFFFVVDL TSETENLDSL KESIITSLSL LPPNALIGLI TYGNVVQLHD LSSETIDRCN VFRGDREYQL EALTEMLTGQ KPTGPGGAAS HLPNAMNKVT PFSLNRFFLP LEQVEFKLNQ LLENLSPDQW SVPAGHRPLR ATGSALNIAS LLLQGCYKNI PARIILFASG PGTVAPGLIV NSELKDPLRS HHDIDSDHAQ HYKKACKFYN QIAQRVAANG HTVDIFAGCY DQIGMSEMKQ LTDSTGGVLL LTDAFSTAIF KQSYLRLFAK DEEGYLKMAF NGNMAVKTSK DLKVQGLIGH ASAVKKTDAN NISESEIGIG ATSTWKMASL SPYHSYAIFF EIANTAANSN PMMSAPGSAD RPHLAYTQFI TTYQHSSGTN RIRVTTVANQ LLPFGTPAIA ASFDQEAAAV LMARIAVHKA ETDDGADVIR WLDRTLIKLC QKYADYNKDD PQSFRLAPNF SLYPQFTYYL RRSQFLSVFN NSPDETAFYR HIFTREDTTN SLIMIQPTLT SFSMEDDPQP VLLDSISVKP NTILLLDTFF FILIYHGEQI AQWRKAGYQD DPQYADFKAL LEEPKLEAAE LLVDRFPLPR FIDTEAGGSQ ARFLLSKLNP SDNYQDMARG GSTIVLTDDV SLQNFMTHLQ QVAVSGQA //