ID SCX2_HOTTS Reviewed; 28 AA. AC P15230; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1990, sequence version 1. DT 05-OCT-2016, entry version 62. DE RecName: Full=Peptide 2; DE AltName: Full=Peptide II; OS Hottentotta tamulus sindicus (Scorpion) (Buthus sindicus). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; OC Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus. OX NCBI_TaxID=42519; RN [1] RP PROTEIN SEQUENCE. RC TISSUE=Venom; RX PubMed=2583272; DOI=10.1016/0014-5793(89)81548-0; RA Fazal A., Beg O.U., Shafqat J., Zaidi Z.H., Joernvall H.; RT "Characterization of two different peptides from the venom of the RT scorpion Buthus sindicus."; RL FEBS Lett. 257:260-262(1989). CC -!- FUNCTION: Blocks potassium channels. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. CC -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. CC Potassium channel inhibitor family. Alpha-KTx 9 subfamily. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; S06668; S06668. DR ProteinModelPortal; P15230; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro. DR GO; GO:0006952; P:defense response; IEA:InterPro. DR GO; GO:0009405; P:pathogenesis; IEA:InterPro. DR InterPro; IPR003614; Scorpion_toxin-like. DR InterPro; IPR008911; Toxin_alpha-KTx_8/9. DR Pfam; PF05453; Toxin_6; 1. DR SUPFAM; SSF57095; SSF57095; 1. PE 1: Evidence at protein level; KW Direct protein sequencing; Ion channel impairing toxin; Neurotoxin; KW Potassium channel impairing toxin; Secreted; Toxin. FT PEPTIDE 1 28 Peptide 2. FT /FTId=PRO_0000044540. SQ SEQUENCE 28 AA; 2968 MW; 2EA9AD78BD39A3B8 CRC64; VGCEEDPMHC KGKQAKPTCC NGVCNCNV //