ID   HXB3_HUMAN              Reviewed;         431 AA.
AC   P14651; A8K567; D3DTV3; O95615; P17484;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   09-JUL-2014, entry version 140.
DE   RecName: Full=Homeobox protein Hox-B3;
DE   AltName: Full=Homeobox protein Hox-2.7;
DE   AltName: Full=Homeobox protein Hox-2G;
GN   Name=HOXB3; Synonyms=HOX2G;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-82.
RX   PubMed=2574852; DOI=10.1093/nar/17.24.10385;
RA   Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E.,
RA   Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.;
RT   "The human HOX gene family.";
RL   Nucleic Acids Res. 17:10385-10402(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-82.
RA   Sauvageau G., Thorsteinsdottir U., Hough M.R., Hugo P., Lawrence H.J.,
RA   Largman C., Humphries R.K.;
RT   "Deregulated expression of HoxB3 in hematopoietic cells causes
RT   defective development of alpha beta T Lymphocytes and progressive
RT   myeloproliferation.";
RL   Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT THR-82.
RA   Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V.,
RA   Kidd J.R., Pakstis A.J.;
RT   "Overall linkage disequilibrium in 33 populations for highly
RT   informative multisite haplotypes spanning the HOXB gene cluster.";
RL   Am. J. Hum. Genet. 67:235-235(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-82.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-253.
RC   TISSUE=Placenta;
RX   PubMed=2570724; DOI=10.1111/j.1432-0436.1989.tb00598.x;
RA   Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M.,
RA   Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A.,
RA   Boncinelli E., Peschle C.;
RT   "Differential expression of human HOX-2 genes along the anterior-
RT   posterior axis in embryonic central nervous system.";
RL   Differentiation 40:191-197(1989).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-253.
RX   PubMed=2576652;
RA   Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA   Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT   "Organization of human class I homeobox genes.";
RL   Genome 31:745-756(1989).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of
CC       a developmental regulatory system that provides cells with
CC       specific positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed in whole embryos and fetuses at 5-9
CC       weeks from conception.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family.
CC   -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
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DR   EMBL; X16667; CAA34657.1; -; mRNA.
DR   EMBL; U59298; AAD10852.1; -; mRNA.
DR   EMBL; AF287967; AAG31555.1; -; Genomic_DNA.
DR   EMBL; AK291182; BAF83871.1; -; mRNA.
DR   EMBL; AK315102; BAG37563.1; -; mRNA.
DR   EMBL; CH471109; EAW94739.1; -; Genomic_DNA.
DR   EMBL; CH471109; EAW94740.1; -; Genomic_DNA.
DR   EMBL; CH471109; EAW94741.1; -; Genomic_DNA.
DR   EMBL; X16175; CAA34297.1; -; Genomic_DNA.
DR   CCDS; CCDS11528.1; -.
DR   PIR; S07543; WJHU2G.
DR   RefSeq; NP_002137.4; NM_002146.4.
DR   RefSeq; XP_005257334.1; XM_005257277.2.
DR   RefSeq; XP_006721917.1; XM_006721854.1.
DR   RefSeq; XP_006721918.1; XM_006721855.1.
DR   UniGene; Hs.654560; -.
DR   ProteinModelPortal; P14651; -.
DR   SMR; P14651; 190-247.
DR   BioGrid; 109453; 2.
DR   STRING; 9606.ENSP00000308252; -.
DR   DMDM; 215274007; -.
DR   PaxDb; P14651; -.
DR   PRIDE; P14651; -.
DR   DNASU; 3213; -.
DR   Ensembl; ENST00000311626; ENSP00000308252; ENSG00000120093.
DR   Ensembl; ENST00000470495; ENSP00000417207; ENSG00000120093.
DR   Ensembl; ENST00000476342; ENSP00000418892; ENSG00000120093.
DR   Ensembl; ENST00000498678; ENSP00000420595; ENSG00000120093.
DR   GeneID; 3213; -.
DR   KEGG; hsa:3213; -.
DR   UCSC; uc002inn.3; human.
DR   CTD; 3213; -.
DR   GeneCards; GC17M046626; -.
DR   HGNC; HGNC:5114; HOXB3.
DR   HPA; CAB009860; -.
DR   MIM; 142966; gene.
DR   neXtProt; NX_P14651; -.
DR   PharmGKB; PA29390; -.
DR   eggNOG; NOG284589; -.
DR   HOGENOM; HOG000252944; -.
DR   HOVERGEN; HBG107984; -.
DR   InParanoid; P14651; -.
DR   KO; K09303; -.
DR   OMA; ATYYDNT; -.
DR   OrthoDB; EOG754HPS; -.
DR   PhylomeDB; P14651; -.
DR   TreeFam; TF315938; -.
DR   ChiTaRS; HOXB3; human.
DR   GeneWiki; HOXB3; -.
DR   GenomeRNAi; 3213; -.
DR   NextBio; 12784; -.
DR   PRO; PR:P14651; -.
DR   ArrayExpress; P14651; -.
DR   Bgee; P14651; -.
DR   CleanEx; HS_HOXB3; -.
DR   Genevestigator; P14651; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0001525; P:angiogenesis; IEP:UniProtKB.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0060216; P:definitive hemopoiesis; IEA:Ensembl.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR   GO; GO:0060324; P:face development; IEA:Ensembl.
DR   GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   GO; GO:0050767; P:regulation of neurogenesis; IEA:Ensembl.
DR   GO; GO:0021546; P:rhombomere development; IEA:Ensembl.
DR   GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.60; -; 1.
DR   InterPro; IPR025281; DUF4074.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR009057; Homeodomain-like.
DR   Pfam; PF13293; DUF4074; 1.
DR   Pfam; PF00046; Homeobox; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus; Polymorphism; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    431       Homeobox protein Hox-B3.
FT                                /FTId=PRO_0000200117.
FT   DNA_BIND    188    247       Homeobox.
FT   MOTIF       129    134       Antp-type hexapeptide.
FT   COMPBIAS    154    178       Gly-rich.
FT   VARIANT      82     82       P -> T (in dbSNP:rs2229304).
FT                                /FTId=VAR_047729.
FT   CONFLICT    199    200       QL -> HV (in Ref. 2; AAD10852).
SQ   SEQUENCE   431 AA;  44340 MW;  56D39C0C9496E65A CRC64;
     MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS ACSLQSLGNA
     APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT SNSSNGGGPS KSGPPKCGPG
     TNSTLTKQIF PWMKESRQTS KLKNNSPGTA EGCGGGGGGG GGGGSGGSGG GGGGGGGGDK
     SPPGSAASKR ARTAYTSAQL VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR
     MKYKKDQKAK GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN
     AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP VYVGGGGYAD
     PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP CEPHPTYTDL SSHHAPPPQG
     RIQEAPKLTH L
//