ID ATP6_CRIGR Reviewed; 226 AA. AC P14413; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 13-OCT-2009, entry version 64. DE RecName: Full=ATP synthase subunit a; DE AltName: Full=F-ATPase protein 6; GN Name=MT-ATP6; Synonyms=ATP6, ATPASE6, MTATP6; OS Cricetulus griseus (Chinese hamster). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Cricetidae; Cricetinae; Cricetulus. OX NCBI_TaxID=10029; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=86304297; PubMed=3017940; RA Breen G.A.M., Miller D.L., Holmans P.L., Welch G.; RT "Mitochondrial DNA of two independent oligomycin-resistant Chinese RT hamster ovary cell lines contains a single nucleotide change in the RT ATPase 6 gene."; RL J. Biol. Chem. 261:11680-11685(1986). CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP CC synthase or Complex V) produces ATP from ADP in the presence of a CC proton gradient across the membrane which is generated by electron CC transport complexes of the respiratory chain. F-type ATPases CC consist of two structural domains, F(1) - containing the CC extramembraneous catalytic core and F(0) - containing the membrane CC proton channel, linked together by a central stalk and a CC peripheral stalk. During catalysis, ATP synthesis in the catalytic CC domain of F(1) is coupled via a rotary mechanism of the central CC stalk subunits to proton translocation. Key component of the CC proton channel; it may play a direct role in the translocation of CC protons across the membrane. CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic CC core - and CF(0) - the membrane proton channel. CF(1) has five CC subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) CC has three main subunits: a, b and c. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein. CC -!- SIMILARITY: Belongs to the ATPase A chain family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M14311; AAA68616.1; -; Genomic_DNA. DR PIR; B25188; B25188. DR HOVERGEN; P14413; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-KW. DR GO; GO:0045263; C:proton-transporting ATP synthase complex, c...; IEA:UniProtKB-KW. DR GO; GO:0015078; F:hydrogen ion transmembrane transporter acti...; IEA:InterPro. DR GO; GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro. DR InterPro; IPR000568; ATPase_F0-cplx_asu. DR Gene3D; G3DSA:1.20.120.220; ATPase_F0_A; 1. DR PANTHER; PTHR11410; ATPase_F0_A; 1. DR Pfam; PF00119; ATP-synt_A; 1. DR PRINTS; PR00123; ATPASEA. DR TIGRFAMs; TIGR01131; ATP_synt_6_or_A; 1. DR PROSITE; PS00449; ATPASE_A; 1. PE 3: Inferred from homology; KW ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane; KW Mitochondrion; Mitochondrion inner membrane; Transmembrane; Transport. FT CHAIN 1 226 ATP synthase subunit a. FT /FTId=PRO_0000082110. FT TRANSMEM 10 30 Potential. FT TRANSMEM 68 88 Potential. FT TRANSMEM 97 117 Potential. FT TRANSMEM 138 158 Potential. FT TRANSMEM 164 184 Potential. FT TRANSMEM 189 209 Potential. SQ SEQUENCE 226 AA; 25040 MW; E90B091319B533F4 CRC64; MNENLFSSFI TPTLMGLPII ILIIMFPPVI MTSSKRLVNN RFHTFQQWLI KLITKQMMAI HSPKGRTWSL MLASLIIFIG STNLLGLLPH TFTPTTQLSM NLGMAIPPWA GAVILGFRHK MKDSLAHFLP QGTPIPLIPM LVIIETISLF IQPMALAVRL TANITAGHLL MHLIGGATLV LTSISLPTAM ITFIILIMLT ILEFAVALIQ AYVFTLLVSL YLHDNT //