ID ATP6_CRIGR STANDARD; PRT; 226 AA. AC P14413; DT 01-JAN-1990 (Rel. 13, Created) DT 01-JAN-1990 (Rel. 13, Last sequence update) DT 01-MAY-2005 (Rel. 47, Last annotation update) DE ATP synthase a chain (EC 3.6.3.14) (ATPase protein 6). GN Name=MTATP6; Synonyms=ATP6; OS Cricetulus griseus (Chinese hamster). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Cricetinae; OC Cricetulus. OX NCBI_TaxID=10029; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=86304297; PubMed=3017940; RA Breen G.A.M., Miller D.L., Holmans P.L., Welch G.; RT "Mitochondrial DNA of two independent oligomycin-resistant Chinese RT hamster ovary cell lines contains a single nucleotide change in the RT ATPase 6 gene."; RL J. Biol. Chem. 261:11680-11685(1986). CC -!- FUNCTION: Key component of the proton channel; it may play a CC direct role in the translocation of protons across the membrane. CC -!- CATALYTIC ACTIVITY: ATP + H(2)O + H(+)(In) = ADP + phosphate + CC H(+)(Out). CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic CC core - and CF(0) - the membrane proton channel. CF(1) has five CC subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) CC has three main subunits: a, b and c. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. Mitochondrial CC inner membrane. CC -!- SIMILARITY: Belongs to the ATPase A chain family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M14311; AAA68616.1; -. DR PIR; B25188; B25188. DR InterPro; IPR000568; ATPsynt_Asub. DR Pfam; PF00119; ATP-synt_A; 1. DR PRINTS; PR00123; ATPASEA. DR TIGRFAMs; TIGR01131; ATP_synt_6_or_A; 1. DR PROSITE; PS00449; ATPASE_A; 1. KW CF(0); Hydrogen ion transport; Ion transport; Mitochondrion; KW Transmembrane; Transport. SQ SEQUENCE 226 AA; 25040 MW; E90B091319B533F4 CRC64; MNENLFSSFI TPTLMGLPII ILIIMFPPVI MTSSKRLVNN RFHTFQQWLI KLITKQMMAI HSPKGRTWSL MLASLIIFIG STNLLGLLPH TFTPTTQLSM NLGMAIPPWA GAVILGFRHK MKDSLAHFLP QGTPIPLIPM LVIIETISLF IQPMALAVRL TANITAGHLL MHLIGGATLV LTSISLPTAM ITFIILIMLT ILEFAVALIQ AYVFTLLVSL YLHDNT //