ID ATP6_CRIGR STANDARD; PRT; 226 AA. AC P14413; DT 01-JAN-1990 (Rel. 13, Created) DT 01-JAN-1990 (Rel. 13, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE ATP SYNTHASE A CHAIN (EC 3.6.1.34) (PROTEIN 6). GN MTATP6 OR ATP6. OS Cricetulus griseus (Chinese hamster). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Rodentia; Sciurognathi; Muridae; Cricetinae; Cricetulus. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 86304297. RA BREEN G.A.M., MILLER D.L., HOLMANS P.L., WELCH G.; RT "Mitochondrial DNA of two independent oligomycin-resistant Chinese RT hamster ovary cell lines contains a single nucleotide change in the RT ATPase 6 gene."; RL J. Biol. Chem. 261:11680-11685(1986). CC -!- FUNCTION: KEY COMPONENT OF THE PROTON CHANNEL; IT MAY PLAY A CC DIRECT ROLE IN THE TRANSLOCATION OF PROTONS ACROSS THE MEMBRANE. CC -!- SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE CC SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1), EPSILON(1). CF(0) CC HAS THREE MAIN SUBUNITS: A, B AND C. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- SIMILARITY: BELONGS TO THE ATPASE A CHAIN FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M14311; AAA68616.1; -. DR PIR; B25188; B25188. DR PFAM; PF00119; ATP-synt_A; 1. DR PROSITE; PS00449; ATPASE_A; 1. KW Hydrogen ion transport; CF(0); Mitochondrion; Transmembrane. SQ SEQUENCE 226 AA; 25039 MW; E6147867 CRC32; MNENLFSSFI TPTLMGLPII ILIIMFPPVI MTSSKRLVNN RFHTFQQWLI KLITKQMMAI HSPKGRTWSL MLASLIIFIG STNLLGLLPH TFTPTTQLSM NLGMAIPPWA GAVILGFRHK MKDSLAHFLP QGTPIPLIPM LVIIETISLF IQPMALAVRL TANITAGHLL MHLIGGATLV LTSISLPTAM ITFIILIMLT ILEFAVALIQ AYVFTLLVSL YLHDNT //