ID   POLG_JAEVN     STANDARD;      PRT;  1440 AA.
AC   P14403; P08769;
DT   01-JAN-1990 (Rel. 13, Created)
DT   01-JAN-1990 (Rel. 13, Last sequence update)
DT   13-SEP-2005 (Rel. 48, Last annotation update)
DE   Genome polyprotein [Contains: Capsid protein C (Core protein);
DE   Envelope protein M (Matrix protein); Major envelope protein E;
DE   Nonstructural protein 1 (NS1); Nonstructural protein 2A (NS2A);
DE   Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3
DE   catalytic subunit (EC 3.4.21.91)] (Fragment).
OS   Japanese encephalitis virus (strain Nakayama).
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae;
OC   Flavivirus; Japanese encephalitis virus group.
OX   NCBI_TaxID=11076;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   MEDLINE=87236200; PubMed=3035787;
RA   McAda P.C., Mason P.W., Schmaljohn C.S., Dalrymple J.M., Mason T.L.,
RA   Fournier M.J.;
RT   "Partial nucleotide sequence of the Japanese encephalitis virus
RT   genome.";
RL   Virology 158:348-360(1987).
CC   -!- FUNCTION: The small proteins NS2A, NS4A and NS4B are hydrophobic,
CC       suggesting a possible membrane-related function. NS5 may play a
CC       role in the viral RNA replication. The NS2B/NS3 protease complex
CC       processes the viral polyprotein.
CC   -!- CATALYTIC ACTIVITY: Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds
CC       in which each of the Xaa can be either Arg or Lys and Yaa can be
CC       either Ser or Ala.
CC   -!- SUBUNIT: NS3 and NS2B form a heterodimer. NS3 is the catalytic
CC       subunit, whereas NS2B strongly stimulates the latter (By
CC       similarity).
CC   -!- PTM: Specific enzymatic cleavages in vivo yield mature proteins
CC       (By similarity).
CC   -!- MISCELLANEOUS: The virion of this virus is a nucleocapsid covered
CC       by a lipoprotein envelope. The envelope contains two proteins: the
CC       protein M and glycoprotein E. The nucleocapsid is a complex of
CC       protein C and mRNA. In immature particles, there are 60
CC       icosaedrally organized trimeric spikes on the surface. Each spike
CC       consists of three heterodimers of envelope protein M precursor
CC       (prM) and envelope protein E (By similarity).
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DR   EMBL; M16574; AAA46251.1; -; Genomic_RNA.
DR   PIR; A27844; GNWVJF.
DR   HSSP; Q88653; 1OKE.
DR   InterPro; IPR001122; Flavi_capsidC.
DR   InterPro; IPR011999; Flavi_glycoE_cen.
DR   InterPro; IPR000069; Flavi_M.
DR   InterPro; IPR001157; Flavi_NS1.
DR   InterPro; IPR000752; Flavi_NS2A.
DR   InterPro; IPR000487; Flavi_NS2B.
DR   InterPro; IPR002535; Flavi_propep.
DR   InterPro; IPR000336; Flv_glyE_Ig-like.
DR   InterPro; IPR011998; Viral_glycoE_cen.
DR   Pfam; PF01003; Flavi_capsid; 1.
DR   Pfam; PF02832; Flavi_glycop_C; 1.
DR   Pfam; PF00869; Flavi_glycoprot; 1.
DR   Pfam; PF01004; Flavi_M; 1.
DR   Pfam; PF00948; Flavi_NS1; 1.
DR   Pfam; PF01005; Flavi_NS2A; 1.
DR   Pfam; PF01002; Flavi_NS2B; 1.
DR   Pfam; PF01570; Flavi_propep; 1.
DR   ProDom; PD001556; Flavi_glycoprotE; 1.
DR   ProDom; PD001496; Flavi_NS1; 1.
KW   ATP-binding; Capsid protein; Core protein; Envelope protein;
KW   Glycoprotein; Helicase; Hydrolase; Nucleotide-binding; Polyprotein;
KW   Structural protein; Transmembrane.
FT   CHAIN        <1     53       Capsid protein C.
FT   PROPEP       54    146
FT   CHAIN       147    222       Envelope protein M.
FT   CHAIN       223    794       Major envelope protein E.
FT   CHAIN       795   1136       Nonstructural protein 1.
FT   CHAIN      1137   1301       Nonstructural protein 2A.
FT   CHAIN      1302   1432       Flavivirin protease NS2B regulatory
FT                                subunit.
FT   CHAIN      1433  >1440       Flavivirin protease NS3 catalytic
FT                                subunit.
FT   CARBOHYD     68     68       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    376    376       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    852    852       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    929    929       N-linked (GlcNAc...) (Potential).
FT   DISULFID    225    252       By similarity.
FT   DISULFID    282    338       By similarity.
FT   DISULFID    296    327       By similarity.
FT   DISULFID    314    343       By similarity.
FT   DISULFID    412    509       By similarity.
FT   DISULFID    526    557       By similarity.
FT   NON_TER       1      1
FT   NON_TER    1440   1440
SQ   SEQUENCE   1440 AA;  158185 MW;  4D489A365A3C2E6E CRC64;
     SVAMKHLTSF KRELGTLIDA VNKRGRKQNK RGGNEGSIMW LASLAVVIAC AGAMKLSNFQ
     GKLLMTVNNT DIADVIVIPN PSKGENRCWV RAIDVGYMCE DTITYECPKL TMGNDPEDVD
     CWCDNQEVYV QYGRCTRTRH SKRSRRSVSV QTHGESSLVN KKEAWLDSTK ATRYLMKTEN
     WIVRNPGYAF LAAILGWMLG SNNGQRRWYF TILLLLVAPA YSFNCLGMGN RDFIEGASGA
     TWVDLVLEGD SCLTIMANDK PTLDVRMINI EAVQLAEVRS YCYHASVTDI STVARCPTTG
     EAHNEKRADS SYVCKQGFTD RGWGNGCGLF GKGSIDTCAK FSCTSKAIGR TIQPENIKYE
     VGIFVHGTTT SENHGNYSAQ VGASQAAKFT VTPNAPSITL KLGDYGEVTL DCEPRSGLNT
     EAFYVMTVGS KSFLVHREWF HDLALPWTPP SSTAWRNREL LMEFEEAHAT KQSVVALGSQ
     EGGLHQALAG AIVVEYSSSV KLTSGHLKCR LKMDKLALKG TTYGMCTEKF SFAKNPADTG
     HGTVVIELSY SGSDGPCKIP IVSVASLNDM TPVGRLVTVN PFVATSSANS KVLVEMEPPF
     GDSYIVVGRG DKQINHHWHK AGSTLGKAFS TTLKGAQRLA ALGDTAWDFG SIGGVFNSIG
     KAVHQVFGGA FRTLFGGMSW ITQGLMGALL LWMGVNARDR SIALAFLATG GVLVFLATNV
     HADTGCAIDI TRKEMRCGSG IFVHNDVEAW VDRYKYLPET PRSLAKIVHK AHKEGVCGVR
     SVTRLEHQMW EAVRDELNVL LKENAVDLSV VVNKPVGRYR SAPKRLSMTQ EKFEMGWKAW
     GKSILFAPEL ANSTFVVDGP ETKECPDEHR AWNSIEIEDF GFGITSTRVW LKIREESTDE
     CDGAIIGTAV KGHVAVHSDL SYWIESRYND TWKLERAVFG EVKSCTWPET HTLWGDGVEE
     SELIIPHTIA GPKSKHNRRE GYKTQNQGPW DENGIVLDFD YCPGTKVTIT EDCGKRGPSV
     RTTTDSGKLI TDWCCRSCSL PPLRFRTENG CWYGMEIRPV RHDETTLVRS QVDAFNGEMV
     DPFQLGLLVM FLATQEVLRK RWTARLTIPA VLGALLVLML GGITYTDLAR YVVLVAAAFA
     EANSGGDVLH LALIAVFKIQ PAFLVMNMLS TRWTNQENVV LVLGAAFFHL ASVDLQIGVH
     GILNAAAIAW MIVRAITFPT TSSVTMPVLA LLTPGMRALY LDTYRIILLV IGICSLLQER
     KKTMAKKKGA VLLGLALTST GWFSPTTIAA GLMVCNPNKK RGWPATEFLS AVGLMFAIVG
     GLAELDIESM SIPFMLAGLM AVSYVVSGKA TDMWLERAAD ISWEMDAAIT GSSRRLDVKL
     DDDGDFHLID DPGVPWKVWV LRMSCIGLAA LTPWAIVPAA FGYWLTLKTT KRGGVFWDTP
//