ID   POLG_JAEVN     STANDARD;      PRT;  1440 AA.
AC   P14403; P08769;
DT   01-JAN-1990 (Rel. 13, Created)
DT   01-JAN-1990 (Rel. 13, Last sequence update)
DT   20-AUG-2001 (Rel. 40, Last annotation update)
DE   GENOME POLYPROTEIN [CONTAINS: CAPSID PROTEIN C (CORE PROTEIN); MATRIX
DE   PROTEIN (ENVELOPE PROTEIN M); MAJOR ENVELOPE PROTEIN E; NONSTRUCTURAL
DE   PROTEINS NS1, NS2A, AND NS2B; PROTEASE/HELICASE (EC 3.4.21.98) (NS3)]
DE   (FRAGMENT).
OS   Japanese encephalitis virus (strain Nakayama).
OC   Viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae;
OC   Flavivirus.
OX   NCBI_TaxID=11076;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=87236200; PubMed=3035787;
RA   McAda P.C., Mason P.W., Schmaljohn C.S., Dalrymple J.M., Mason T.L.,
RA   Fournier M.J.;
RT   "Partial nucleotide sequence of the Japanese encephalitis virus
RT   genome.";
RL   Virology 158:348-360(1987).
CC   -!- FUNCTION: THE SMALL PROTEINS NS2A, NS2B, NS4A AND NS4B ARE
CC       HYDROPHOBIC, SUGGESTING A POSSIBLE MEMBRANE-RELATED FUNCTION.
CC       NS3 AND NS5 MAY PLAY A ROLE IN THE VIRAL RNA REPLICATION.
CC   -!- CATALYTIC ACTIVITY: HYDROLYSIS OF FOUR PEPTIDE BONDS IN THE VIRAL
CC       PRECURSOR POLYPROTEIN, COMMONLY WITH ASP OR GLU IN THE P6
CC       POSITION, CYS OR THR IN P1 AND SER OR ALA IN P1'.
CC   -!- SUBUNIT: THE VIRION OF THIS VIRUS IS A NUCLEOCAPSID COVERED BY A
CC       LIPOPROTEIN ENVELOPE. THE ENVELOPE CONSISTS OF TWO PROTEINS:
CC       PROTEIN M AND GLYCOPROTEIN E. THE NUCLEOCAPSID IS A COMPLEX OF
CC       PROTEIN C AND MRNA.
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DR   EMBL; M16574; AAA46251.1; -.
DR   PIR; A27844; GNWVJF.
DR   HSSP; P14336; 1SVB.
DR   InterPro; IPR000069; Flavi_M.
DR   InterPro; IPR001157; Flavi_NS1.
DR   InterPro; IPR000752; Flavi_NS2A.
DR   InterPro; IPR000487; Flavi_NS2B.
DR   InterPro; IPR000336; Flavi_glycoprotE.
DR   InterPro; IPR002535; Flavi_propep.
DR   Pfam; PF00869; Flavi_glycoprot; 1.
DR   Pfam; PF01004; Flavi_M; 1.
DR   Pfam; PF00948; Flavi_NS1; 1.
DR   Pfam; PF01005; Flavi_NS2A; 1.
DR   Pfam; PF01002; Flavi_NS2B; 1.
DR   Pfam; PF01570; Flavi_propep; 1.
DR   ProDom; PD001496; Flavi_NS1; 1.
DR   ProDom; PD001556; Flavi_glycoprotE; 1.
KW   Polyprotein; Glycoprotein; Core protein; Coat protein;
KW   Envelope protein; Hydrolase; Helicase; ATP-binding; Transmembrane;
KW   Nonstructural protein.
FT   NON_TER       1      1
FT   CHAIN        <1     53       CAPSID PROTEIN C.
FT   PROPEP       54    146
FT   CHAIN       147    222       ENVELOPE GLYCOPROTEIN M.
FT   CHAIN       223    794       MAJOR ENVELOPE PROTEIN E.
FT   CHAIN       795   1136       NONSTRUCTURAL PROTEIN NS1.
FT   CHAIN      1137   1301       NONSTRUCTURAL PROTEIN NS2A.
FT   CHAIN      1302   1432       NONSTRUCTURAL PROTEIN NS2B.
FT   CHAIN      1433  >1440       PROTEASE/HELICASE (NS3).
FT   DISULFID    225    252       BY SIMILARITY.
FT   DISULFID    282    338       BY SIMILARITY.
FT   DISULFID    296    327       BY SIMILARITY.
FT   DISULFID    314    343       BY SIMILARITY.
FT   DISULFID    412    509       BY SIMILARITY.
FT   DISULFID    526    557       BY SIMILARITY.
FT   CARBOHYD     68     68       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    376    376       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    852    852       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    929    929       N-LINKED (GLCNAC...) (POTENTIAL).
FT   NON_TER    1440   1440
SQ   SEQUENCE   1440 AA;  158184 MW;  4D489A365A3C2E6E CRC64;
     SVAMKHLTSF KRELGTLIDA VNKRGRKQNK RGGNEGSIMW LASLAVVIAC AGAMKLSNFQ
     GKLLMTVNNT DIADVIVIPN PSKGENRCWV RAIDVGYMCE DTITYECPKL TMGNDPEDVD
     CWCDNQEVYV QYGRCTRTRH SKRSRRSVSV QTHGESSLVN KKEAWLDSTK ATRYLMKTEN
     WIVRNPGYAF LAAILGWMLG SNNGQRRWYF TILLLLVAPA YSFNCLGMGN RDFIEGASGA
     TWVDLVLEGD SCLTIMANDK PTLDVRMINI EAVQLAEVRS YCYHASVTDI STVARCPTTG
     EAHNEKRADS SYVCKQGFTD RGWGNGCGLF GKGSIDTCAK FSCTSKAIGR TIQPENIKYE
     VGIFVHGTTT SENHGNYSAQ VGASQAAKFT VTPNAPSITL KLGDYGEVTL DCEPRSGLNT
     EAFYVMTVGS KSFLVHREWF HDLALPWTPP SSTAWRNREL LMEFEEAHAT KQSVVALGSQ
     EGGLHQALAG AIVVEYSSSV KLTSGHLKCR LKMDKLALKG TTYGMCTEKF SFAKNPADTG
     HGTVVIELSY SGSDGPCKIP IVSVASLNDM TPVGRLVTVN PFVATSSANS KVLVEMEPPF
     GDSYIVVGRG DKQINHHWHK AGSTLGKAFS TTLKGAQRLA ALGDTAWDFG SIGGVFNSIG
     KAVHQVFGGA FRTLFGGMSW ITQGLMGALL LWMGVNARDR SIALAFLATG GVLVFLATNV
     HADTGCAIDI TRKEMRCGSG IFVHNDVEAW VDRYKYLPET PRSLAKIVHK AHKEGVCGVR
     SVTRLEHQMW EAVRDELNVL LKENAVDLSV VVNKPVGRYR SAPKRLSMTQ EKFEMGWKAW
     GKSILFAPEL ANSTFVVDGP ETKECPDEHR AWNSIEIEDF GFGITSTRVW LKIREESTDE
     CDGAIIGTAV KGHVAVHSDL SYWIESRYND TWKLERAVFG EVKSCTWPET HTLWGDGVEE
     SELIIPHTIA GPKSKHNRRE GYKTQNQGPW DENGIVLDFD YCPGTKVTIT EDCGKRGPSV
     RTTTDSGKLI TDWCCRSCSL PPLRFRTENG CWYGMEIRPV RHDETTLVRS QVDAFNGEMV
     DPFQLGLLVM FLATQEVLRK RWTARLTIPA VLGALLVLML GGITYTDLAR YVVLVAAAFA
     EANSGGDVLH LALIAVFKIQ PAFLVMNMLS TRWTNQENVV LVLGAAFFHL ASVDLQIGVH
     GILNAAAIAW MIVRAITFPT TSSVTMPVLA LLTPGMRALY LDTYRIILLV IGICSLLQER
     KKTMAKKKGA VLLGLALTST GWFSPTTIAA GLMVCNPNKK RGWPATEFLS AVGLMFAIVG
     GLAELDIESM SIPFMLAGLM AVSYVVSGKA TDMWLERAAD ISWEMDAAIT GSSRRLDVKL
     DDDGDFHLID DPGVPWKVWV LRMSCIGLAA LTPWAIVPAA FGYWLTLKTT KRGGVFWDTP
//