ID HBA_PTEPO Reviewed; 141 AA. AC P14390; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 16-SEP-2015, entry version 76. DE RecName: Full=Hemoglobin subunit alpha; DE AltName: Full=Alpha-globin; DE AltName: Full=Hemoglobin alpha chain; GN Name=HBA; OS Pteropus poliocephalus (Grey-headed flying fox). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; OC Pteropodidae; Pteropodinae; Pteropus. OX NCBI_TaxID=9403; RN [1] RP PROTEIN SEQUENCE. RX PubMed=3228493; RA Kleinschmidt T., Sgouros J.G., Pettigrew J.D., Braunitzer G.; RT "The primary structure of the hemoglobin from the grey-headed flying RT fox (Pteropus poliocephalus) and the black flying fox (P. alecto, RT Megachiroptera)."; RL Biol. Chem. Hoppe-Seyler 369:975-984(1988). CC -!- FUNCTION: Involved in oxygen transport from the lung to the CC various peripheral tissues. CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains. CC -!- TISSUE SPECIFICITY: Red blood cells. CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE- CC ProRule:PRU00238}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; S01310; HAFXG. DR ProteinModelPortal; P14390; -. DR PRIDE; P14390; -. DR HOVERGEN; HBG009709; -. DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW. DR Gene3D; 1.10.490.10; -; 1. DR InterPro; IPR000971; Globin. DR InterPro; IPR009050; Globin-like. DR InterPro; IPR012292; Globin/Proto. DR InterPro; IPR002338; Haemoglobin_a. DR InterPro; IPR002339; Haemoglobin_pi. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00612; ALPHAHAEM. DR PRINTS; PR00815; PIHAEM. DR SUPFAM; SSF46458; SSF46458; 1. DR PROSITE; PS01033; GLOBIN; 1. PE 1: Evidence at protein level; KW Acetylation; Direct protein sequencing; Heme; Iron; Metal-binding; KW Oxygen transport; Phosphoprotein; Transport. FT CHAIN 1 141 Hemoglobin subunit alpha. FT /FTId=PRO_0000052745. FT METAL 58 58 Iron (heme distal ligand). FT METAL 87 87 Iron (heme proximal ligand). FT MOD_RES 3 3 Phosphoserine. FT {ECO:0000250|UniProtKB:P69905}. FT MOD_RES 7 7 N6-succinyllysine. FT {ECO:0000250|UniProtKB:P01942}. FT MOD_RES 11 11 N6-succinyllysine. FT {ECO:0000250|UniProtKB:P01942}. FT MOD_RES 16 16 N6-acetyllysine; alternate. FT {ECO:0000250|UniProtKB:P69905}. FT MOD_RES 16 16 N6-succinyllysine; alternate. FT {ECO:0000250|UniProtKB:P01942}. FT MOD_RES 24 24 Phosphotyrosine. FT {ECO:0000250|UniProtKB:P69905}. FT MOD_RES 35 35 Phosphoserine. FT {ECO:0000250|UniProtKB:P69905}. FT MOD_RES 40 40 N6-succinyllysine. FT {ECO:0000250|UniProtKB:P01942}. SQ SEQUENCE 141 AA; 15222 MW; 9F5AEF633458A46E CRC64; VLSSTDKSNV KAAWDKVGGN VGEYGAEALE RMFLSFPTTK TYFPHFDLAH GSSQVKAHGK KVGDALTNAV GHMDDLPGAL SALSDLHAYK LRVDPVNFKL LSHCLLVTLA NHLPNDFTPA VHASLDKFLA SVSTVLTSKY R //