ID HBA_PTEPO Reviewed; 141 AA. AC P14390; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 24-NOV-2009, entry version 57. DE RecName: Full=Hemoglobin subunit alpha; DE AltName: Full=Hemoglobin alpha chain; DE AltName: Full=Alpha-globin; GN Name=HBA; OS Pteropus poliocephalus (Grey-headed flying fox). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; OC Pteropodidae; Pteropodinae; Pteropus. OX NCBI_TaxID=9403; RN [1] RP PROTEIN SEQUENCE. RX MEDLINE=89149963; PubMed=3228493; RA Kleinschmidt T., Sgouros J.G., Pettigrew J.D., Braunitzer G.; RT "The primary structure of the hemoglobin from the grey-headed flying RT fox (Pteropus poliocephalus) and the black flying fox (P. alecto, RT Megachiroptera)."; RL Biol. Chem. Hoppe-Seyler 369:975-984(1988). CC -!- FUNCTION: Involved in oxygen transport from the lung to the CC various peripheral tissues. CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains. CC -!- TISSUE SPECIFICITY: Red blood cells. CC -!- SIMILARITY: Belongs to the globin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; S01310; HAFXG. DR SMR; P14390; 1-141. DR HOVERGEN; P14390; -. DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW. DR GO; GO:0015671; P:oxygen transport; IEA:UniProtKB-KW. DR InterPro; IPR012292; Globin. DR InterPro; IPR009050; Globin-like. DR InterPro; IPR000971; Globin_subset. DR InterPro; IPR002338; Haemoglobin_a. DR InterPro; IPR018331; Haemoglobin_alpha_chain. DR InterPro; IPR002339; Haemoglobin_pi. DR Gene3D; G3DSA:1.10.490.10; Globin_related; 1. DR PANTHER; PTHR11442:SF14; Pi_haem; 1. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00612; ALPHAHAEM. DR PRINTS; PR00815; PIHAEM. DR PROSITE; PS01033; GLOBIN; 1. PE 1: Evidence at protein level; KW Acetylation; Direct protein sequencing; Heme; Iron; Metal-binding; KW Oxygen transport; Transport. FT CHAIN 1 141 Hemoglobin subunit alpha. FT /FTId=PRO_0000052745. FT METAL 58 58 Iron (heme distal ligand). FT METAL 87 87 Iron (heme proximal ligand). FT MOD_RES 16 16 N6-acetyllysine (By similarity). SQ SEQUENCE 141 AA; 15222 MW; 9F5AEF633458A46E CRC64; VLSSTDKSNV KAAWDKVGGN VGEYGAEALE RMFLSFPTTK TYFPHFDLAH GSSQVKAHGK KVGDALTNAV GHMDDLPGAL SALSDLHAYK LRVDPVNFKL LSHCLLVTLA NHLPNDFTPA VHASLDKFLA SVSTVLTSKY R //