ID HBA_PTEPO Reviewed; 141 AA. AC P14390; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 12-JUN-2007, entry version 45. DE Hemoglobin subunit alpha (Hemoglobin alpha chain) (Alpha-globin). GN Name=HBA; OS Pteropus poliocephalus (Grey-headed flying fox). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; OC Pteropodidae; Pteropodinae; Pteropus. OX NCBI_TaxID=9403; RN [1] RP PROTEIN SEQUENCE. RX MEDLINE=89149963; PubMed=3228493; RA Kleinschmidt T., Sgouros J.G., Pettigrew J.D., Braunitzer G.; RT "The primary structure of the hemoglobin from the grey-headed flying RT fox (Pteropus poliocephalus) and the black flying fox (P. alecto, RT Megachiroptera)."; RL Biol. Chem. Hoppe-Seyler 369:975-984(1988). CC -!- FUNCTION: Involved in oxygen transport from the lung to the CC various peripheral tissues. CC -!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains. CC -!- TISSUE SPECIFICITY: Red blood cells. CC -!- SIMILARITY: Belongs to the globin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; S01310; HAFXG. DR HSSP; P01958; 1IWH. DR SMR; P14390; 1-141. DR InterPro; IPR002338; Alpha_haem. DR InterPro; IPR000971; Globin. DR InterPro; IPR013314; Globin_fish. DR InterPro; IPR012292; Globin_related. DR InterPro; IPR002339; Pi_haem. DR Gene3D; G3DSA:1.10.490.10; Globin_related; 1. DR PANTHER; PTHR11442:SF14; Pi_haem; 1. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00612; ALPHAHAEM. DR PRINTS; PR01906; FISHGLOBIN. DR PRINTS; PR00815; PIHAEM. DR PROSITE; PS01033; GLOBIN; 1. KW Direct protein sequencing; Heme; Iron; Metal-binding; KW Oxygen transport; Transport. FT CHAIN 1 141 Hemoglobin subunit alpha. FT /FTId=PRO_0000052745. FT METAL 58 58 Iron (heme distal ligand). FT METAL 87 87 Iron (heme proximal ligand). SQ SEQUENCE 141 AA; 15222 MW; 9F5AEF633458A46E CRC64; VLSSTDKSNV KAAWDKVGGN VGEYGAEALE RMFLSFPTTK TYFPHFDLAH GSSQVKAHGK KVGDALTNAV GHMDDLPGAL SALSDLHAYK LRVDPVNFKL LSHCLLVTLA NHLPNDFTPA VHASLDKFLA SVSTVLTSKY R //