ID TSP_MOUSE Reviewed; 124 AA. AC P13438; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 2. DT 27-MAY-2015, entry version 86. DE RecName: Full=Trophoblast-specific protein alpha; DE Flags: Precursor; GN Name=Tpbpa; Synonyms=Tpbp; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=CD-1; RX PubMed=3215514; DOI=10.1101/gad.2.12a.1639; RA Lescisin K.R., Varmuza S., Rossant J.; RT "Isolation and characterization of a novel trophoblast-specific cDNA RT in the mouse."; RL Genes Dev. 2:1639-1646(1988). CC -!- FUNCTION: It may be a growth factor/hormone, perhaps involved in CC interaction between the maternal and fetal systems in maintenance CC of pregnancy. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17071; CAA34917.1; -; mRNA. DR CCDS; CCDS36693.1; -. DR PIR; A30043; A30043. DR UniGene; Mm.2372; -. DR ProteinModelPortal; P13438; -. DR PaxDb; P13438; -. DR PRIDE; P13438; -. DR MGI; MGI:98795; Tpbpa. DR eggNOG; COG4870; -. DR HOGENOM; HOG000115233; -. DR HOVERGEN; HBG004479; -. DR InParanoid; P13438; -. DR PhylomeDB; P13438; -. DR PRO; PR:P13438; -. DR Proteomes; UP000000589; Unplaced. DR CleanEx; MM_TPBPA; -. DR Genevestigator; P13438; -. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005764; C:lysosome; IBA:GO_Central. DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central. DR GO; GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI. DR GO; GO:0007254; P:JNK cascade; IDA:MGI. DR GO; GO:0051603; P:proteolysis involved in cellular protein catabolic process; IBA:GO_Central. DR InterPro; IPR013128; Peptidase_C1A. DR PANTHER; PTHR12411; PTHR12411; 1. PE 2: Evidence at transcript level; KW Complete proteome; Reference proteome; Secreted; Signal. FT SIGNAL 1 18 {ECO:0000255}. FT CHAIN 19 124 Trophoblast-specific protein alpha. FT /FTId=PRO_0000022600. SQ SEQUENCE 124 AA; 13948 MW; BB5E3AFF955AA2C4 CRC64; MTPTIFLVIL CLGVASAVIV PEAQLDAELQ EQKDKEVLIK AVWSKFMKTN KLHSSENDQE TEGSNIEMSA SGQLTDEELM KIMTTVLHPM FEEEENKPQP VVDDPEFEDY TESGDGFFVP NQPQ //