ID TSP_MOUSE Reviewed; 124 AA. AC P13438; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 2. DT 13-SEP-2023, entry version 108. DE RecName: Full=Trophoblast-specific protein alpha; DE Flags: Precursor; GN Name=Tpbpa; Synonyms=Tpbp; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=CD-1; RX PubMed=3215514; DOI=10.1101/gad.2.12a.1639; RA Lescisin K.R., Varmuza S., Rossant J.; RT "Isolation and characterization of a novel trophoblast-specific cDNA in the RT mouse."; RL Genes Dev. 2:1639-1646(1988). CC -!- FUNCTION: It may be a growth factor/hormone, perhaps involved in CC interaction between the maternal and fetal systems in maintenance of CC pregnancy. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X17071; CAA34917.1; -; mRNA. DR CCDS; CCDS36693.1; -. DR PIR; A30043; A30043. DR AlphaFoldDB; P13438; -. DR SMR; P13438; -. DR STRING; 10090.ENSMUSP00000021885; -. DR PaxDb; P13438; -. DR AGR; MGI:98795; -. DR MGI; MGI:98795; Tpbpa. DR InParanoid; P13438; -. DR PhylomeDB; P13438; -. DR ChiTaRS; Tpbpa; mouse. DR PRO; PR:P13438; -. DR Proteomes; UP000000589; Unplaced. DR RNAct; P13438; Protein. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell. DR GO; GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI. DR GO; GO:0007254; P:JNK cascade; IDA:MGI. PE 2: Evidence at transcript level; KW Reference proteome; Secreted; Signal. FT SIGNAL 1..18 FT /evidence="ECO:0000255" FT CHAIN 19..124 FT /note="Trophoblast-specific protein alpha" FT /id="PRO_0000022600" FT REGION 51..74 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 91..124 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 124 AA; 13948 MW; BB5E3AFF955AA2C4 CRC64; MTPTIFLVIL CLGVASAVIV PEAQLDAELQ EQKDKEVLIK AVWSKFMKTN KLHSSENDQE TEGSNIEMSA SGQLTDEELM KIMTTVLHPM FEEEENKPQP VVDDPEFEDY TESGDGFFVP NQPQ //