ID PAG_BACAN STANDARD; PRT; 764 AA. AC P13423; DT 01-JAN-1990 (REL. 13, CREATED) DT 01-JAN-1990 (REL. 13, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE PROTECTIVE ANTIGEN PRECURSOR (PA). GN PAG. OS BACILLUS ANTHRACIS. OG PLASMID PXO1. OC PROKARYOTA; FIRMICUTES; ENDOSPORE-FORMING RODS AND COCCI; BACILLACEAE. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 89172073. RA WELKOS S.L., LOWE J.R., EDEN-MCCUTCHAN F., VODKIN M., LEPPLA S.H., RA SCHMIDT J.J.; RL GENE 69:287-300(1988). RN [2] RP DOMAINS. RX MEDLINE; 91332080. RA SINGH Y., KLIMPEL K.R., QUINN C.P., CHAUDHARY V.K., LEPPLA S.H.; RL J. BIOL. CHEM. 266:15493-15497(1991). CC -!- FUNCTION: ONE OF THE THREE PROTEINS COMPOSING THE ANTHRAX TOXIN, CC AGENT WHICH INFECTS MANY MAMMALIAN SPECIES AND THAT MAY CAUSE CC DEATH. PA IS THOUGT TO BIND TO RECEPTORS OF SENSITIVE EUKARYOTIC CC CELLS, THEREBY FACILITATING THE INTERNALIZATION OF LF OR EF. PA CC ASSOCIATED WITH LF CAUSES DEATH WHEN INJECTED, PA ASSOCIATED WITH CC EF PRODUCES EDEMA. PA INDUCES IMMUNITY TO INFECTION WITH ANTHRAX. CC -!- SUBUNIT: ANTHRAX TOXIN IS COMPOSED OF THREE DISTINCT PROTEINS, A CC PROTECTIVE ANTIGEN (PA), A LETHAL FACTOR (LF) AND AN EDEMA FACTOR CC (EF). NONE OF THESE IS TOXIC BY ITSELF. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- DOMAIN: THE C-TERMINAL PART OF PA IS REQUIRED FOR RECEPTOR BINDING CC AND TOXIC ACTIVITY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M22589; G143282; -. KW TOXIN; PLASMID; SIGNAL. FT SIGNAL 1 29 FT CHAIN 30 764 PROTECTIVE ANTIGEN. SQ SEQUENCE 764 AA; 85811 MW; FC841E77 CRC32; MKKRKVLIPL MALSTILVSS TGNLEVIQAE VKQENRLLNE SESSSQGLLG YYFSDLNFQA PMVVTSSTTG DLSIPSSELE NIPSENQYFQ SAIWSGFIKV KKSDEYTFAT SADNHVTMWV DDQEVINKAS NSNKIRLEKG RLYQIKIQYQ RENPTEKGLD FKLYWTDSQN KKEVISSDNL QLPELKQKSS NSRKKRSTSA GPTVPDRDND GIPDSLEVEG YTVDVKNKRT FLSPWISNIH EKKGLTKYKS SPEKWSTASD PYSDFEKVTG RIDKNVSPEA RHPLVAAYPI VHVDMENIIL SKNEDQSTQN TDSETRTISK NTSTSRTHTS EVHGNAEVHA SFFDIGGSVS AGFSNSNSST VAIDHSLSLA GERTWAETMG LNTADTARLN ANIRYVNTGT APIYNVLPTT SLVLGKNQTL ATIKAKENQL SQILAPNNYY PSKNLAPIAL NAQDDFSSTP ITMNYNQFLE LEKTKQLRLD TDQVYGNIAT YNFENGRVRV DTGSNWSEVL PQIQETTARI IFNGKDLNLV ERRIAAVNPS DPLETTKPDM TLKEALKIAF GFNEPNGNLQ YQGKDITEFD FNFDQQTSQN IKNQLAELNA TNIYTVLDKI KLNAKMNILI RDKRFHYDRN NIAVGADESV VKEAHREVIN SSTEGLLLNI DKDIRKILSG YIVEIEDTEG LKEVINDRYD MLNISSLRQD GKTFIDFKKY NDKLPLYISN PNYKVNVYAV TKENTIINPS ENGDTSTNGI KKILIFSKKG YEIG //