ID PAG_BACAN STANDARD; PRT; 764 AA. AC P13423; DT 01-JAN-1990 (REL. 13, CREATED) DT 01-JAN-1990 (REL. 13, LAST SEQUENCE UPDATE) DT 01-FEB-1995 (REL. 31, LAST ANNOTATION UPDATE) DE PROTECTIVE ANTIGEN PRECURSOR (PA). GN PAG. OS BACILLUS ANTHRACIS. OG PLASMID PXO1. OC PROKARYOTA; FIRMICUTES; ENDOSPORE-FORMING RODS AND COCCI; BACILLACEAE. RN [1] RP SEQUENCE FROM N.A. RM 89172073 RA WELKOS S.L., LOWE J.R., EDEN-MCCUTCHAN F., VODKIN M., LEPPLA S.H., RA SCHMIDT J.J.; RL GENE 69:287-300(1988). RN [2] RP DOMAINS. RM 91332080 RA SINGH Y., KLIMPEL K.R., QUINN C.P., CHAUDHARY V.K., LEPPLA S.H.; RL J. BIOL. CHEM. 266:15493-15497(1991). CC -!- FUNCTION: PA IS ONE OF THREE PROTEINS COMPRISING ANTHRAX TOXIN. CC THE THREE PROTEINS ALONE ARE NONTOXIC. PA INDUCES IMMUNITY TO CC INFECTION. THE LETHAL TOXIN, WHICH CONTAINS PA AND LF, CAUSES CC DEATH IN RATS, GUINEA PIGS AND RABBITS. CC -!- SUBUNIT: ASSOCIATES WITH THE PROTECTIVE ANTIGEN (PA) TO ENTER THE CC HOST CELL. PA MUST BIND A CELLULAR RECEPTOR AND BE ACTIVATED BY CC PROTEOLYTIC CLEAVAGE, IN ORDER TO PERMIT THE COMPETITIVE BINDING CC OF LF AND EF TO PA. THE ENTIRE TOXIN COMPLEX ENTERS THE CELL BY CC ENDOCYTOSIS. CC -!- THE C-TERMINAL PART OF PA IS REQUIRED FOR RECEPTOR BINDING AND CC TOXIC ACTIVITY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M22589; BAPAG. KW TOXIN; PLASMID; SIGNAL. FT SIGNAL 1 29 FT CHAIN 30 764 PROTECTIVE ANTIGEN. SQ SEQUENCE 764 AA; 85811 MW; 2966257 CN; MKKRKVLIPL MALSTILVSS TGNLEVIQAE VKQENRLLNE SESSSQGLLG YYFSDLNFQA PMVVTSSTTG DLSIPSSELE NIPSENQYFQ SAIWSGFIKV KKSDEYTFAT SADNHVTMWV DDQEVINKAS NSNKIRLEKG RLYQIKIQYQ RENPTEKGLD FKLYWTDSQN KKEVISSDNL QLPELKQKSS NSRKKRSTSA GPTVPDRDND GIPDSLEVEG YTVDVKNKRT FLSPWISNIH EKKGLTKYKS SPEKWSTASD PYSDFEKVTG RIDKNVSPEA RHPLVAAYPI VHVDMENIIL SKNEDQSTQN TDSETRTISK NTSTSRTHTS EVHGNAEVHA SFFDIGGSVS AGFSNSNSST VAIDHSLSLA GERTWAETMG LNTADTARLN ANIRYVNTGT APIYNVLPTT SLVLGKNQTL ATIKAKENQL SQILAPNNYY PSKNLAPIAL NAQDDFSSTP ITMNYNQFLE LEKTKQLRLD TDQVYGNIAT YNFENGRVRV DTGSNWSEVL PQIQETTARI IFNGKDLNLV ERRIAAVNPS DPLETTKPDM TLKEALKIAF GFNEPNGNLQ YQGKDITEFD FNFDQQTSQN IKNQLAELNA TNIYTVLDKI KLNAKMNILI RDKRFHYDRN NIAVGADESV VKEAHREVIN SSTEGLLLNI DKDIRKILSG YIVEIEDTEG LKEVINDRYD MLNISSLRQD GKTFIDFKKY NDKLPLYISN PNYKVNVYAV TKENTIINPS ENGDTSTNGI KKILIFSKKG YEIG //