ID MYSP_DIRIM Reviewed; 848 AA. AC P13392; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1994, sequence version 2. DT 02-DEC-2020, entry version 70. DE RecName: Full=Paramyosin; DE Flags: Fragment; OS Dirofilaria immitis (Canine heartworm). OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Dirofilaria. OX NCBI_TaxID=6287; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2325708; DOI=10.1016/0166-6851(90)90030-p; RA Limberger R.J., McReynolds L.A.; RT "Filarial paramyosin: cDNA sequences from Dirofilaria immitis and RT Onchocerca volvulus."; RL Mol. Biochem. Parasitol. 38:271-280(1990). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 18-96. RX PubMed=2527335; DOI=10.1016/0166-6851(89)90139-4; RA Grandea A.G. III, Tuyen L.K., Asikin N., Davis T.B., Philipp M., Cohen C., RA McReynolds L.A.; RT "A lambda gt11 cDNA recombinant that encodes Dirofilaria immitis RT paramyosin."; RL Mol. Biochem. Parasitol. 35:31-41(1989). CC -!- FUNCTION: Paramyosin is a major structural component of many thick CC filaments isolated from invertebrate muscles. CC -!- SUBUNIT: Homodimer. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the CC myofibrils. CC -!- SIMILARITY: Belongs to the paramyosin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M29733; AAA28299.1; -; mRNA. DR EMBL; J04009; AAA28300.1; -; mRNA. DR PIR; A44972; A44972. DR PIR; A45548; A45548. DR SMR; P13392; -. DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell. DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW. DR GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW. DR GO; GO:0003774; F:motor activity; IEA:InterPro. DR InterPro; IPR002928; Myosin_tail. DR Pfam; PF01576; Myosin_tail_1; 1. PE 2: Evidence at transcript level; KW Coiled coil; Cytoplasm; Disulfide bond; Motor protein; Muscle protein; KW Myosin; Thick filament. FT CHAIN <1..>848 FT /note="Paramyosin" FT /id="PRO_0000211248" FT REGION <1..9 FT /note="Nonhelical region" FT /evidence="ECO:0000255" FT REGION 834..848 FT /note="Nonhelical region" FT /evidence="ECO:0000255" FT COILED 10..833 FT /evidence="ECO:0000255" FT DISULFID 105 FT /note="Interchain" FT /evidence="ECO:0000255" FT DISULFID 594 FT /note="Interchain" FT /evidence="ECO:0000255" FT NON_TER 1 FT NON_TER 848 SQ SEQUENCE 848 AA; 98008 MW; BF32B7120157FA50 CRC64; AFGSMSVADL GSLTRLEDKI RLLQEDLESE RELRNRIERE RADLSVQLIA LTDRLEDAEG TTDSQIESNR KREAELQKLR KLLEESQLEN EDAMNVLRKK HQDACLDYAE QIEQLQKKNS KIDRERQRLQ HEVIELTATI DQLQKDKHLA EKAAERFEAQ TIELSNKVED LNRHVNDLAQ QRQRLQAENN DLLKEIHDQK VQLDNLQHVK YQLAQQLEEA RRRLEDAERE RSQLQAQLHQ VQLELDSVRT ALDEESAARA EAEHKLALAN TEITQWKSKF DAEVALHHEE VEDLRKKMLQ KQAEYEEQIE IMLQKISQLE KAKSRLQSEV EVLIVDLEKA QNTIAILERA KEQLEKTVNE LKVRIDELTV ELEAAQREAR AALAELQKMK NLYEKAIEQK EALARENKKL QDDLHEAKEA LADANRKLHE LDLENARLAG EIRELQTALK ESEAARRDAE NRAQRALAEL QQLRIEMERR LQEKEEEMEA LRKNMQFEID RLTAALADAE ARMKAEISRL KKKYQAEIAE LEMTVDNLNR ANIEAQKTIK KQSEQLKILQ ASLEDTQRQL QQTLDQYALA QRKVSALSAE LEECKVALDN AIRARKQAEI DLEEANARIT DLVSINNNLT AIKNKLETEL STAQADLDEA TKELHAADER ANRALADAAR AVEQLHEEQE HSMKIDALRK SLEEQVKQLQ VQIQEAEAAA LLGGKRVIAK LETRIRDLET ALDEETRRHK ETQGALRKKD RRIKEVQMQV DEEHKMFVMA QDTADRLLEK LNIQKWQLGE AESLTMANLQ RVRRYQRELE DAEGRADQAE SSLHLIRAKH RSSVVTGKNA SASKIYVL //