ID ESM4_DROME Reviewed; 152 AA. AC P13095; Q9VBI9; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 09-JAN-2007, entry version 48. DE Enhancer of split m4 protein (E(spl)m4). GN Name=m4; ORFNames=CG6099; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=89231619; PubMed=2540957; RA Klaembt C., Knust E., Tietze K., Campos-Ortega J.A.; RT "Closely related transcripts encoded by the neurogenic gene complex RT enhancer of split of Drosophila melanogaster."; RL EMBO J. 8:203-210(1989). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] RP GENOME REANNOTATION. RX MEDLINE=22426069; PubMed=12537572; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). CC -!- FUNCTION: Part of the Notch signaling pathway. CC -!- INTERACTION: CC Q9VKC4:CG6792; NbExp=1; IntAct=EBI-132651, EBI-120128; CC Q9XYR0:Traf1; NbExp=1; IntAct=EBI-132651, EBI-120454; CC -!- DEVELOPMENTAL STAGE: Expressed at the time when separation of CC neural and epidermal precursors cells occurs. Mesectodermal CC expression appears shortly before the onset of gastrulation. In CC imaginal disks, expression is seen primarily within presumptive CC proneural clusters of eye-antennal, wing and leg disks. CC -!- SIMILARITY: Belongs to the M4-like protein family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X16551; CAA34551.1; -; Genomic_DNA. DR EMBL; AE014297; AAF56551.1; -; Genomic_DNA. DR PIR; S03630; S03630. DR UniGene; Dm.25014; -. DR DIP; DIP:23216N; -. DR IntAct; P13095; -. DR GermOnline; CG6099; Drosophila melanogaster. DR Ensembl; CG6099; Drosophila melanogaster. DR KEGG; dme:CG6099-PA; -. DR FlyBase; FBgn0002629; m4. DR BioCyc; DMEL-XXX-02:DMEL-XXX-02-013502-MONOMER; -. DR GO; GO:0005634; C:nucleus; TAS:FlyBase. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0001708; P:cell fate specification; IMP:FlyBase. DR GO; GO:0007219; P:Notch signaling pathway; IMP:FlyBase. DR GO; GO:0007423; P:sensory organ development; IMP:FlyBase. KW Coiled coil; Complete proteome; Developmental protein; KW Differentiation; Neurogenesis; Notch signaling pathway. FT CHAIN 1 152 Enhancer of split m4 protein. FT /FTId=PRO_0000087059. FT COILED 23 61 Potential. SQ SEQUENCE 152 AA; 17250 MW; D7F642838BD2DA0C CRC64; MCQNKINTNN TMTIKSNKKL SYSVKKLLQK IFKQQQRVEE EQNLKNALKA NSLESLESME NSRNADLESA SICASLESCE NEANERLSQS CEIEDYDFEQ LPTVPVHFVR TAHGTFFWTA VSDLPADNDL VEPLYCSTSN AIAIPQDRWV QA //