ID RL23_HALMA STANDARD; PRT; 84 AA. AC P12732; Q5V1S6; DT 01-OCT-1989 (Rel. 12, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 13-SEP-2005 (Rel. 48, Last annotation update) DE 50S ribosomal protein L23P (Hmal23) (Hl25) (L21). GN Name=rpl23p; OrderedLocusNames=rrnAC1609; OS Haloarcula marismortui (Halobacterium marismortui). OC Archaea; Euryarchaeota; Halobacteria; Halobacteriales; OC Halobacteriaceae; Haloarcula. OX NCBI_TaxID=2238; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=90153945; PubMed=2406244; RA Arndt E., Kroemer W., Hatakeyama T.; RT "Organization and nucleotide sequence of a gene cluster coding for RT eight ribosomal proteins in the archaebacterium Halobacterium RT marismortui."; RL J. Biol. Chem. 265:3034-3039(1990). RN [2] RP PROTEIN SEQUENCE. RX MEDLINE=88166754; PubMed=3350019; RA Hatakeyama T., Kimura M.; RT "Complete amino acid sequences of the ribosomal proteins L25, L29 and RT L31 from the archaebacterium Halobacterium marismortui."; RL Eur. J. Biochem. 172:703-711(1988). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 43049; RX PubMed=15520287; DOI=10.1101/gr.2700304; RA Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., RA Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., RA Date S.V., Marcotte E., Hood L., Ng W.V.; RT "Genome sequence of Haloarcula marismortui: a halophilic archaeon from RT the Dead Sea."; RL Genome Res. 14:2221-2234(2004). RN [4] RP PROTEIN SEQUENCE OF 1-22. RX MEDLINE=89062418; PubMed=3196689; RA Walsh M.J., McDougall J., Wittmann-Liebold B.; RT "Extended N-terminal sequencing of proteins of archaebacterial RT ribosomes blotted from two-dimensional gels onto glass fiber and RT poly(vinylidene difluoride) membrane."; RL Biochemistry 27:6867-6876(1988). RN [5] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT. RC STRAIN=ATCC 43049; RX MEDLINE=20396344; PubMed=10937989; DOI=10.1126/science.289.5481.905; RA Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.; RT "The complete atomic structure of the large ribosomal subunit at 2.4 A RT resolution."; RL Science 289:905-920(2000). RN [6] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT. RC STRAIN=ATCC 43049; RX MEDLINE=20396345; PubMed=10937990; DOI=10.1126/science.289.5481.920; RA Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.; RT "The structural basis of ribosome activity in peptide bond RT synthesis."; RL Science 289:920-930(2000). RN [7] RP X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT. RC STRAIN=ATCC 43049; RX MEDLINE=21864647; PubMed=11828326; DOI=10.1038/nsb758; RA Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., RA Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.; RT "A pre-translocational intermediate in protein synthesis observed in RT crystals of enzymatically active 50S subunits."; RL Nat. Struct. Biol. 9:225-230(2002). RN [8] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT. RC STRAIN=ATCC 43049; RX MEDLINE=21376068; PubMed=11483524; DOI=10.1093/emboj/20.15.4214; RA Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.; RT "The kink-turn: a new RNA secondary structure motif."; RL EMBO J. 20:4214-4221(2001). RN [9] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX RP WITH FOUR MACROLIDE ANTIBIOTICS. RC STRAIN=ATCC 43049; RX MEDLINE=22146556; PubMed=12150912; DOI=10.1016/S1097-2765(02)00570-1; RA Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., RA Steitz T.A.; RT "The structures of four macrolide antibiotics bound to the large RT ribosomal subunit."; RL Mol. Cell 10:117-128(2002). RN [10] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT. RC STRAIN=ATCC 43049; RX MEDLINE=22199842; PubMed=12185246; DOI=10.1073/pnas.172404099; RA Hansen J.L., Schmeing T.M., Moore P.B., Steitz T.A.; RT "Structural insights into peptide bond formation."; RL Proc. Natl. Acad. Sci. U.S.A. 99:11670-11675(2002). RN [11] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX RP WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER. RC STRAIN=ATCC 43049; RX MEDLINE=22745177; PubMed=12860128; DOI=10.1016/S0022-2836(03)00668-5; RA Hansen J.L., Moore P.B., Steitz T.A.; RT "Structures of five antibiotics bound at the peptidyl transferase RT center of the large ribosomal subunit."; RL J. Mol. Biol. 330:1061-1075(2003). RN [12] RP X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO RP DIFFERENT E SITE SUBSTRATES. RX PubMed=14561884; DOI=10.1261/rna.5120503; RA Schmeing T.M., Moore P.B., Steitz T.A.; RT "Structures of deacylated tRNA mimics bound to the E site of the large RT ribosomal subunit."; RL RNA 9:1345-1352(2003). CC -!- FUNCTION: Binds to a specific region on the 23S rRNA. Located at CC the polypeptide exit tunnel on the outside of the subunit. CC -!- SUBUNIT: Part of the 50S ribosomal subunit. Interacts with protein CC L29 and weakly with protein L39e. CC -!- SIMILARITY: Belongs to the ribosomal protein L23P family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J05222; AAA86861.1; -; Genomic_DNA. DR EMBL; AY596297; AAV46526.1; -; Genomic_DNA. DR PIR; E35063; R5HS23. DR PDB; 1FFK; X-ray; P=-. DR PDB; 1JJ2; X-ray; R=1-84. DR PDB; 1K73; X-ray; T=1-84. DR PDB; 1K8A; X-ray; T=1-84. DR PDB; 1K9M; X-ray; T=1-84. DR PDB; 1KC8; X-ray; T=1-84. DR PDB; 1KD1; X-ray; T=1-84. DR PDB; 1KQS; X-ray; R=1-84. DR PDB; 1M1K; X-ray; T=1-84. DR PDB; 1M90; X-ray; T=1-84. DR PDB; 1N8R; X-ray; T=1-84. DR PDB; 1NJI; X-ray; T=1-84. DR PDB; 1Q7Y; X-ray; T=1-84. DR PDB; 1Q81; X-ray; T=1-84. DR PDB; 1Q82; X-ray; T=1-84. DR PDB; 1Q86; X-ray; T=1-84. DR PDB; 1QVF; X-ray; R=1-84. DR PDB; 1QVG; X-ray; R=1-84. DR PDB; 1S72; X-ray; S=1-84. DR PDB; 1W2B; X-ray; R=1-84. DR InterPro; IPR012678; L23_L15e_core. DR InterPro; IPR012677; Nucl_bd_a/b_plat. DR InterPro; IPR001014; Ribosomal_L23. DR Pfam; PF00276; Ribosomal_L23; 1. DR ProDom; PD001141; Ribosomal_L23; 1. DR PROSITE; PS00050; RIBOSOMAL_L23; 1. KW 3D-structure; Complete proteome; Direct protein sequencing; KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding. FT INIT_MET 0 0 SQ SEQUENCE 84 AA; 9470 MW; 97671B9D1AC2DA2E CRC64; SWDVIKHPHV TEKAMNDMDF QNKLQFAVDD RASKGEVADA VEEQYDVTVE QVNTQNTMDG EKKAVVRLSE DDDAQEVASR IGVF //