ID DNLI_SCHPO STANDARD; PRT; 768 AA. AC P12000; DT 01-OCT-1989 (REL. 12, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-AUG-1992 (REL. 23, LAST ANNOTATION UPDATE) DE DNA LIGASE (EC 6.5.1.1) (POLYDEOXYRIBONUCLEOTIDE SYNTHASE (ATP)). GN CDC17. OS SCHIZOSACCHAROMYCES POMBE (FISSION YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTINA; HEMIASCOMYCETES. RN [1] RP SEQUENCE FROM N.A. RM 87161837 RA BARKER D.G., WHITE J.H.M., JOHNSTON L.H.; RL EUR. J. BIOCHEM. 162:659-667(1987). CC -!- FUNCTION: THIS PROTEIN SEALS DURING DNA REPLICATION, DNA CC RECOMBINATION AND DNA REPAIR NICKS IN DOUBLE-STRANDED DNA. CC -!- CATALYTIC ACTIVITY: ATP + (DEOXYRIBONUCLEOTIDE)(N) + CC (DEOXYRIBONUCLEOTIDE)(M) = AMP + PYROPHOSPHATE + CC (DEOXYRIBONUCLEOTIDE)(N+M). CC -!- SIMILARITY: HIGH TO OTHER EUKARYOTIC AND VIRUSES DNA LIGASES, LOW CC TO PHAGES LIGASES. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X05107; SPCDC17. DR PIR; A29066; A29066. DR PROSITE; PS00333; DNA_LIGASE. KW DNA REPAIR; DNA REPLICATION; DNA RECOMBINATION; CELL DIVISION; LIGASE; KW ATP-BINDING. FT BINDING 416 416 AMP (BY SIMILARITY). SQ SEQUENCE 768 AA; 86581 MW; 3113862 CN; MRTVFSQIPR FKQVNQYIRM STRQSDISNF FISSASHKSE HVEVSQSSSD SKNVDGRSTS EKRKVESVKL VDESKHNNHD DTGTQNVERE NNIVSEAKKQ KTLGSSSSSS DAVSSNNDSG ASTPIPLPIK EPPLESNARN DKLKGHATFA EMVKAFTKIE NTSKRLEIID IMGTYFFGIL RDHPSDLLAC VYLSINKLGP DYSGLELGIG ESIIMKAIGE STGQTLQQIK LSFHKVGDLG LVAQTSRQNQ PTMFKPAALT IPFLFDSLKK IAQMSGNQSQ NRKIGVIKRL LSSCEGAEPK YLIRALEGKL RLQLAEKTIL VALANATAQY HADKNGEKLS QQDRIEGEQI LRDVYCQLPS YDLIVPHLIE HGLGTLRETC KLTPGIPTKP MLAKPTKQIS EVLNTFDQAA FTCEYKYDGE RAQVHFTEDG KFYVFSRNSE NMSVRYPDIS VSVSKWKKPD ARSFILDCEA VGWDRDENKI LPFQKLATRK RKDVKIGDIK VRACLFAFDI LYLNGQPLLE TPLNERRKLL YSMFQPSTGD FTFAKHSDQK SIESIEEFLE ESVKDSCEGL MVKMLEGPDS HYEPSKRSRH WLKVKKDYLS GVGDSLDLIV IGAYYGKGKR TSVYGAFLLG CYDPDTETVQ SICKLGTGFS EEHLETFYNQ LKDIVISKKK DFYAHSDVPA HQPDVWFEPK YLWEVLAADL SLSPVYKAAI GYVQEDKGIS LRFPRFIRIR EDKSWEDATT SEQVSEFYRS QVAYSQKEKE GSPAAEDY //