ID DNLI$SCHPO STANDARD; PRT; 768 AA. AC P12000; DT 01-OCT-1989 (REL. 12, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-APR-1990 (REL. 14, LAST ANNOTATION UPDATE) DE DNA LIGASE (EC 6.5.1.1) (POLYDEOXYRIBONUCLEOTIDE SYNTHASE (ATP)) DE (GENE NAME: CDC17). OS FISSION YEAST (SCHIZOSACCHAROMYCES POMBE). OC EUKARYOTA; FUNGI; ASCOMYCETES; HEMIASCOMYCETES. RN [1] (SEQUENCE FROM N.A.) RA BARKER D.G., WHITE J.H.M., JOHNSTON L.H.; RL EUR. J. BIOCHEM. 162:659-667(1987). CC -!- FUNCTION: THIS PROTEIN SEALS DURING DNA REPLICATION, DNA CC RECOMBINATION AND DNA REPAIR NICKS IN DOUBLE-STRANDED DNA. CC -!- CATALYTIC ACTIVITY: ATP + (DEOXYRIBONUCLEOTIDE)(N) + CC (DEOXYRIBONUCLEOTIDE)(M) = AMP + PYROPHOSPHATE + CC (DEOXYRIBONUCLEOTIDE)(N+M). CC -!- SIMILARITY: HIGH TO YEAST AND VACCINIA VIRUS DNA LIGASES, LOW TO CC PHAGES T4 AND T7 LIGASES. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X05107; SPCDC17. DR PROSITE; PS00333; DNA_LIGASE. KW DNA REPAIR; DNA REPLICATION; DNA RECOMBINATION; CELL DIVISION; LIGASE; KW ATP-BINDING. FT BINDING 573 573 ATP (BY HOMOLOGY). SQ SEQUENCE 768 AA; 86580 MW; 3113862 CN; MRTVFSQIPR FKQVNQYIRM STRQSDISNF FISSASHKSE HVEVSQSSSD SKNVDGRSTS EKRKVESVKL VDESKHNNHD DTGTQNVERE NNIVSEAKKQ KTLGSSSSSS DAVSSNNDSG ASTPIPLPIK EPPLESNARN DKLKGHATFA EMVKAFTKIE NTSKRLEIID IMGTYFFGIL RDHPSDLLAC VYLSINKLGP DYSGLELGIG ESIIMKAIGE STGQTLQQIK LSFHKVGDLG LVAQTSRQNQ PTMFKPAALT IPFLFDSLKK IAQMSGNQSQ NRKIGVIKRL LSSCEGAEPK YLIRALEGKL RLQLAEKTIL VALANATAQY HADKNGEKLS QQDRIEGEQI LRDVYCQLPS YDLIVPHLIE HGLGTLRETC KLTPGIPTKP MLAKPTKQIS EVLNTFDQAA FTCEYKYDGE RAQVHFTEDG KFYVFSRNSE NMSVRYPDIS VSVSKWKKPD ARSFILDCEA VGWDRDENKI LPFQKLATRK RKDVKIGDIK VRACLFAFDI LYLNGQPLLE TPLNERRKLL YSMFQPSTGD FTFAKHSDQK SIESIEEFLE ESVKDSCEGL MVKMLEGPDS HYEPSKRSRH WLKVKKDYLS GVGDSLDLIV IGAYYGKGKR TSVYGAFLLG CYDPDTETVQ SICKLGTGFS EEHLETFYNQ LKDIVISKKK DFYAHSDVPA HQPDVWFEPK YLWEVLAADL SLSPVYKAAI GYVQEDKGIS LRFPRFIRIR EDKSWEDATT SEQVSEFYRS QVAYSQKEKE GSPAAEDY //