ID DNLI_SCHPO STANDARD; PRT; 768 AA. AC P12000; DT 01-OCT-1989 (Rel. 12, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE DNA LIGASE (EC 6.5.1.1) (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [ATP]). GN CDC17 OR SPAC57A10.12C OR SPAC20G8.01. OS Schizosaccharomyces pombe (Fission yeast). OC Eukaryota; Fungi; Ascomycota; Archiascomycetes; OC Schizosaccharomycetales; Schizosaccharomycetaceae; OC Schizosaccharomyces. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 87161837. RA BARKER D.G., WHITE J.H.M., JOHNSTON L.H.; RT "Molecular characterisation of the DNA ligase gene, CDC17, from the RT fission yeast Schizosaccharomyces pombe."; RL Eur. J. Biochem. 162:659-667(1987). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=972; RA BADCOCK K., CHURCHER C.M., WOOD V., BARRELL B.G., RAJANDREAM M.A.; RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: THIS PROTEIN SEALS DURING DNA REPLICATION, DNA CC RECOMBINATION AND DNA REPAIR NICKS IN DOUBLE-STRANDED DNA. CC -!- CATALYTIC ACTIVITY: ATP + (DEOXYRIBONUCLEOTIDE)(N) + CC (DEOXYRIBONUCLEOTIDE)(M) = AMP + PYROPHOSPHATE + CC (DEOXYRIBONUCLEOTIDE)(N+M). CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- SIMILARITY: BELONGS TO THE ATP-DEPENDENT DNA LIGASE FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X05107; CAA28754.1; -. DR EMBL; Z94864; CAB08176.1; -. DR EMBL; Z95334; CAB08595.1; -. DR PIR; A29066; A29066. DR PFAM; PF01068; DNA_ligase; 1. DR PROSITE; PS00333; DNA_LIGASE_A2; 1. DR PROSITE; PS00697; DNA_LIGASE_A1; 1. KW DNA repair; DNA replication; DNA recombination; Cell division; Ligase; KW ATP-binding; Nuclear protein. FT BINDING 416 416 AMP (BY SIMILARITY). SQ SEQUENCE 768 AA; 86581 MW; FDD67CF7 CRC32; MRTVFSQIPR FKQVNQYIRM STRQSDISNF FISSASHKSE HVEVSQSSSD SKNVDGRSTS EKRKVESVKL VDESKHNNHD DTGTQNVERE NNIVSEAKKQ KTLGSSSSSS DAVSSNNDSG ASTPIPLPIK EPPLESNARN DKLKGHATFA EMVKAFTKIE NTSKRLEIID IMGTYFFGIL RDHPSDLLAC VYLSINKLGP DYSGLELGIG ESIIMKAIGE STGQTLQQIK LSFHKVGDLG LVAQTSRQNQ PTMFKPAALT IPFLFDSLKK IAQMSGNQSQ NRKIGVIKRL LSSCEGAEPK YLIRALEGKL RLQLAEKTIL VALANATAQY HADKNGEKLS QQDRIEGEQI LRDVYCQLPS YDLIVPHLIE HGLGTLRETC KLTPGIPTKP MLAKPTKQIS EVLNTFDQAA FTCEYKYDGE RAQVHFTEDG KFYVFSRNSE NMSVRYPDIS VSVSKWKKPD ARSFILDCEA VGWDRDENKI LPFQKLATRK RKDVKIGDIK VRACLFAFDI LYLNGQPLLE TPLNERRKLL YSMFQPSTGD FTFAKHSDQK SIESIEEFLE ESVKDSCEGL MVKMLEGPDS HYEPSKRSRH WLKVKKDYLS GVGDSLDLIV IGAYYGKGKR TSVYGAFLLG CYDPDTETVQ SICKLGTGFS EEHLETFYNQ LKDIVISKKK DFYAHSDVPA HQPDVWFEPK YLWEVLAADL SLSPVYKAAI GYVQEDKGIS LRFPRFIRIR EDKSWEDATT SEQVSEFYRS QVAYSQKEKE GSPAAEDY //