ID KAR1_YEAST STANDARD; PRT; 433 AA. AC P11927; DT 01-OCT-1989 (REL. 12, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE CELL DIVISION CONTROL PROTEIN KAR1. GN KAR1. OS SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTINA; HEMIASCOMYCETES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 87159524. RA ROSE M.D., FINK G.R.; RL CELL 48:1047-1060(1987). RN [2] RP FUNCTION. RX MEDLINE; 94350199. RA VALLEN E.A., HO W., WINEY M., ROSE M.D.; RL GENETICS 137:407-422(1994). RN [3] RP FUNCTION. RC STRAIN=S288C; RX MEDLINE; 95181541. RA SPANG A., COURTNEY I., GREIN K., MATZNER M., SCHIEBEL E.; RL J. CELL BIOL. 128:863-877(1995). CC -!- FUNCTION: KAR1 IS REQUIRED FOR FUNCTION OF BOTH INTRANUCLEAR AND CC EXTRANUCLEAR MICROTUBULES. KAR1 HELPS LOCALIZE CDC31 TO THE CC SPINDLE POLE BODY (SPB), CDC31 THEN INITIATES SPB DUPLICATION VIA CC INTERACTION WITH A DOWNSTREAM EFFECTOR. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M15683; M15683. DR PIR; A26455; A26455. DR LISTA; SC00515; KAR1. DR SGD; L0000886; KAR1. KW CELL DIVISION; MICROTUBULES; MITOSIS. SQ SEQUENCE 433 AA; 50681 MW; 982333 CN; MNVTSPKDGN HSFSKKNRFN TNKPRFHKLN EQAQSINLPE DRDSIVSSNT TSIMTDDAFD YNEGIASRTK NINSDSDRSN DTIKQNNYNK RETGYNPFYN GSGINQRYTQ FRKREFEPTL AENKAEEYIS DEDNVKIDED NIENELQFTP KIKEASILRS SLLGQRNVLN TRNPKSKESH IKVKPIINNK SSSQRKSSVA LRKQLGKPLP LPYLNSPNSD STPTLQRKEE VFTDEVLQKK RELIESKWHR LLFHDKKMVE KKLESLREYE RKRMPPRGTD VSSSEQDNSF KISTPTKSYV SLEQKPLPNL SAMNNFNDVT DNKEKEETNN NILKFQAQRD PLQILQSEIE MHTKKLDTII ELLKDDTDSK EKRKVVTNDN AAPEQMVNKG WRKNVMMIYK KSGNIMKKYR EYFLWTICIL ILLYCNIYVY YRF //