ID   IP3R_MOUSE     STANDARD;      PRT;  2749 AA.
AC   P11881; Q99LG5;
DT   01-OCT-1989 (Rel. 12, Created)
DT   01-OCT-1989 (Rel. 12, Last sequence update)
DT   01-MAR-2002 (Rel. 41, Last annotation update)
DE   Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5-
DE   trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform
DE   1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400)
DE   (Purkinje cell protein 1).
GN   ITPR1 OR INSP3R.
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORM 1).
RC   TISSUE=Purkinje cells;
RX   MEDLINE=90044039; PubMed=2554142;
RA   Furuichi T., Yoshikawa S., Miyawaki A., Wada K., Maeda N.,
RA   Mikoshiba K.;
RT   "Primary structure and functional expression of the inositol 1,4,5-
RT   trisphosphate-binding protein P400.";
RL   Nature 342:32-38(1989).
RN   [2]
RP   SEQUENCE FROM N.A. (ISOFORM 1).
RC   STRAIN=ICR; TISSUE=Cerebellum;
RX   MEDLINE=89345101; PubMed=2762133;
RA   Furuichi T., Yoshikawa S., Mikoshiba K.;
RT   "Nucleotide sequence of cDNA encoding P400 protein in the mouse
RT   cerebellum.";
RL   Nucleic Acids Res. 17:5385-5386(1989).
RN   [3]
RP   SEQUENCE OF 318-332 AND 1692-1731 FROM N.A., AND ALTERNATIVE SPLICING.
RC   STRAIN=ICR;
RX   MEDLINE=91296797; PubMed=1648733;
RA   Nakagawa T., Okano H., Furuichi T., Aruga J., Mikoshiba K.;
RT   "The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are
RT   expressed in a tissue-specific and developmentally specific manner.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:6244-6248(1991).
RN   [4]
RP   SEQUENCE OF 2098-2749 FROM N.A.
RA   Strausberg R.;
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RECEPTOR FOR INOSITOL 1,4,5-TRISPHOSPHATE, A SECOND
CC       MESSENGER THAT MEDIATES THE RELEASE OF INTRACELLULAR CALCIUM.
CC   -!- SUBUNIT: HOMOTETRAMER.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein. Endoplasmic
CC       reticulum.
CC   -!- ALTERNATIVE PRODUCTS: 8 ISOFORMS; 1/SISIIABC (SHOWN HERE), 2/SI-
CC       SIIABC, 3/SISIIAC, 4/SI-SIIAC, 5/SISIIA, 6/SI-SIIA, 7/SISII- AND
CC       8/SI-SII-; MAY BE PRODUCED BY ALTERNATIVE SPLICING. THERE IS A
CC       COMBINATION OF TWO ALTERNATIVE SPLICED DOMAINS AT SITE SI AND SITE
CC       SII (A, B AND C).
CC   -!- DOMAIN: THE RECEPTOR CONTAINS A CALCIUM CHANNEL IN ITS C-TERMINAL
CC       EXTREMITY. ITS LARGE N-TERMINAL CYTOPLASMIC REGION HAS THE LIGAND-
CC       BINDING SITE IN THE N-TERMINUS AND MODULATORY SITES IN THE MIDDLE
CC       PORTION IMMEDIATELY UPSTREAM OF THE CHANNEL REGION.
CC   -!- PTM: PHOSPHORYLATED BY CYCLIC-AMP KINASE. PHOSPHORYLATION PREVENTS
CC       THE LIGAND-INDUCED OPENING OF THE CALCIUM CHANNELS.
CC   -!- PTM: PHOSPHORYLATED ON TYROSINE RESIDUES (BY SIMILARITY).
CC   -!- MISCELLANEOUS: CALCIUM APPEARS TO INHIBIT LIGAND BINDING TO THE
CC       RECEPTOR, MOST PROBABLY BY INTERACTING WITH A DISTINCT
CC       CALCIUM-BINDING PROTEIN WHICH THEN INHIBITS THE RECEPTOR.
CC   -!- SIMILARITY: BELONGS TO THE INSP3 RECEPTOR FAMILY.
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DR   EMBL; X15373; CAA33433.1; -.
DR   EMBL; M75986; AAA39316.1; -.
DR   EMBL; M75987; AAA39317.1; -.
DR   EMBL; BC003271; AAH03271.1; ALT_INIT.
DR   PIR; S04844; ACMSIT.
DR   MGD; MGI:96623; Itpr1.
DR   InterPro; IPR000636; Cation_chan_non_lig.
DR   InterPro; IPR001682; Channel_pore_Ca_Na.
DR   InterPro; IPR000493; InsP3_bind_receptor.
DR   InterPro; IPR003608; MIR.
DR   InterPro; IPR000699; RYDR_ITPR.
DR   Pfam; PF00520; ion_trans; 1.
DR   Pfam; PF02815; MIR; 4.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
KW   Receptor; Transmembrane; Phosphorylation; Endoplasmic reticulum;
KW   Ionic channel; Ion transport; Calcium channel; Alternative splicing.
FT   DOMAIN        1   2273       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM   2274   2294       POTENTIAL.
FT   DOMAIN     2295   2305       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM   2306   2326       POTENTIAL.
FT   DOMAIN     2327   2352       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM   2353   2373       POTENTIAL.
FT   DOMAIN     2374   2396       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM   2397   2417       POTENTIAL.
FT   DOMAIN     2418   2439       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM   2440   2460       POTENTIAL.
FT   DOMAIN     2461   2569       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM   2570   2590       POTENTIAL.
FT   DOMAIN     2591   2749       CYTOPLASMIC (POTENTIAL).
FT   MOD_RES     482    482       PHOSPHORYLATION (POTENTIAL).
FT   MOD_RES    1588   1588       PHOSPHORYLATION (BY PKA) (POTENTIAL).
FT   MOD_RES    1755   1755       PHOSPHORYLATION (BY PKA) (POTENTIAL).
FT   MOD_RES    2655   2655       PHOSPHORYLATION (POTENTIAL).
FT   VARSPLIC    318    332       MISSING (IN ISOFORM 2, ISOFORM 4, ISOFORM
FT                                6 AND ISOFORM 8).
FT   VARSPLIC   1692   1714       MISSING (IN ISOFORM 7 AND ISOFORM 8).
FT   VARSPLIC   1715   1715       MISSING (IN ISOFORM 3, ISOFORM 4, ISOFORM
FT                                5, ISOFORM 6, ISOFORM 7 AND ISOFORM 8).
FT   VARSPLIC   1716   1731       MISSING (IN ISOFORM 5, ISOFORM 6, ISOFORM
FT                                7 AND ISOFORM 8).
FT   CONFLICT   2675   2675       L -> P (IN REF. 4).
SQ   SEQUENCE   2749 AA;  313193 MW;  47E5F24BCD5F4153 CRC64;
     MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL
     CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV
     RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE
     GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT
     SPLKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL
     VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE
     LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH
     NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT
     NADILIETKL VLSRFEFEGV STGENALEAG EDEEEVWLFW RDSNKEIRSK SVRELAQDAK
     EGQKEDRDIL SYYRYQLNLF ARMCLDRQYL AINEISGQLD VDLILRCMSD ENLPYDLRAS
     FCRLMLHMHV DRDPQEQVTP VKYARLWSEI PSEIAIDDYD SSGTSKDEIK ERFAQTMEFV
     EEYLRDVVCQ RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHV
     TTIFPISKMT KGEENKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA PEGNVKQAEP
     EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQSSE TSSGNSSQEG
     PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL
     QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD
     EPMDGASGEN EHKKTEEGTS KPLKHESTSS YNYRVVKEIL IRLSKLCVQE SASVRKSRKQ
     QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ NQALLHKHIN
     LFLKPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK FLQTIVKAEG
     KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP LMYHIHLVEL
     LAVCTEGKNV YTEIKCNSLL PLDDIVRVVT HEDCIPEVKI AYINFLNHCY VDTEVEMKEI
     YTSNHMWKLF ENFLVDICRA CNNTSDRKHA DSILEKYVTE IVMSIVTTFF SSPFSDQSTT
     LQTRQPVFVQ LLQGVFRVYH CNWLMPSQKA SVESCIRVLS DVAKSRAIAI PVDLDSQVNN
     LFLKSHNIVQ KTALNWRLSA RNAARRDSVL AASRDYRNII ERLQDIVSAL EDRLRPLVQA
     ELSVLVDVLH RPELLFPENT DARRKCESGG FICKLIKHTK QLLEENEEKL CIKVLQTLRE
     MMTKDRGYGE KQISIDESEN AELPQAPEAE NSTEQELEPS PPLRQLEDHK RGEALRQILV
     NRYYGNIRPS GRRESLTSFG NGPLSPGGPS KPGGGGGGPG SSSTSRGEMS LAEVQCHLDK
     EGASNLVIDL IMNASSDRVF HESILLAIAL LEGGNTTIQH SFFCRLTEDK KSEKFFKVFY
     DRMKVAQQEI KATVTVNTSD LGNKKKDDEV DRDAPSRKKA KEPTTQITEE VRDQLLEASA
     ATRKAFTTFR READPDDHYQ SGEGTQATTD KAKDDLEMSA VITIMQPILR FLQLLCENHN
     RDLQNFLRCQ NNKTNYNLVC ETLQFLDCIC GSTTGGLGLL GLYINEKNVA LINQTLESLT
     EYCQGPCHEN QNCIATHESN GIDIITALIL NDINPLGKKR MDLVLELKNN ASKLLLAIME
     SRHDSENAER ILYNMRPKEL VEVIKKAYMQ GEVEFEDGEN GEDGAASPRN VGHNIYILAH
     QLARHNKELQ TMLKPGGQVD GDEALEFYAK HTAQIEIVRL DRTMEQIVFP VPSICEFLTK
     ESKLRIYYTT ERDEQGSKIN DFFLRSEDLF NEMNWQKKLR AQPVLYWCAR NMSFWSSISF
     NLAVLMNLLV AFFYPFKGVR GGTLEPHWSG LLWTAMLISL AIVIALPKPH GIRALIASTI
     LRLIFSVGLQ PTLFLLGAFN VCNKIIFLMS FVGNCGTFTR GYRAMVLDVE FLYHLLYLLI
     CAMGLFVHEF FYSLLLFDLV YREETLLNVI KSVTRNGRSI ILTAVLALIL VYLFSIVGYL
     FFKDDFILEV DRLPNETAVP ETGESLANDF LYSDVCRVET GENCTSPAPK EELLPAEETE
     QDKEHTCETL LMCIVTVLSH GLRSGGGVGD VLRKPSKEEP LFAARVIYDL LFFFMVIIIV
     LNLIFGVIID TFADLRSEKQ KKEEILKTTC FICGLERDKF DNKTVTFEEH IKEEHNMWHY
     LCFIVLVKVK DSTEYTGPES YVAEMIRERN LDWFLRMRAM SLVSSDSEGE QNELRNLQEK
     LESTMKLVTN LSGQLSELKD QMTEQRKQKQ RIGLLGHPPH MNVNPQQPA
//