ID   IP3R_MOUSE     STANDARD;      PRT;  2749 AA.
AC   P11881;
DT   01-OCT-1989 (REL. 12, CREATED)
DT   01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE)
DT   15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE)
DE   INOSITOL 1,4,5-TRISPHOSPHATE-BINDING PROTEIN TYPE 1 RECEPTOR
DE   (INOSITOL 1,4,5-TRISPHOSPHATE-BINDING PROTEIN P(400)) (TYPE 1 INSP3
DE   RECEPTOR).
GN   INSP3R OR ITPR1.
OS   MUS MUSCULUS (MOUSE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; RODENTIA.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=PURKINJE CELLS;
RX   MEDLINE; 90044039.
RA   FURUICHI T., YOSHIKAWA S., MIYAWAKI A., WADA K., MAEDA N.,
RA   MIKOSHIBA K.;
RL   NATURE 342:32-38(1989).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   STRAIN=ICR; TISSUE=CEREBELLUM;
RX   MEDLINE; 89345101.
RA   FURUICHI T., YOSHIKAWA S., MIKOSHIBA K.;
RL   NUCLEIC ACIDS RES. 17:5385-5386(1989).
RN   [3]
RP   SEQUENCE OF 318-332 AND 1692-1731 FROM N.A., AND ALTERNATIVE SPLICING.
RC   STRAIN=JCR;
RX   MEDLINE; 91296797.
RA   NAKAGAWA T., OKANO H., FURUICHI T., ARUGA J., MIKOSHIBA K.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 88:6244-6248(1991).
CC   -!- FUNCTION: RECEPTOR FOR INOSITOL 1,4,5-TRISPHOSPHATE, A SECOND
CC       MESSENGER THAT MEDIATES THE RELEASE OF INTRACELLULAR CALCIUM.
CC       THE RECEPTOR CONTAINS A CALCIUM CHANNEL IN ITS C-TERMINAL
CC       EXTREMITY. ITS LARGE N-TERMINAL CYTOPLASMIC REGION HAS THE LIGAND-
CC       BINDING SITE IN THE N-TERMINUS AND MODULATORY SITES IN THE MIDDLE
CC       PORTION IMMEDIATELY UPSTREAM OF THE CHANNEL REGION.
CC   -!- SUBUNIT: HOMOTETRAMER.
CC   -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. ENDOPLASMIC
CC       RETICULUM.
CC   -!- PTM: PHOSPHORYLATED BY CYCLIC-AMP KINASE. PHOSPHORYLATION PREVENTS
CC       THE LIGAND-INDUCED OPENING OF THE CALCIUM CHANNELS.
CC   -!- CALCIUM APPEARS TO INHIBIT LIGAND BINDING TO THE RECEPTOR, MOST
CC       PROBABLY BY INTERACTING WITH A DISTINCT CALCIUM-BINDING PROTEIN
CC       WHICH THEN INHIBITS THE RECEPTOR.
CC   -!- ALTERNATIVE PRODUCTS: ADDITIONAL SUBTYPES OF INSP3R ARISE BY
CC       ALTERNATIVE SPLICING OF THE SAME GENE.
CC   -!- SIMILARITY: TO RYANODINE RECEPTOR.
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DR   EMBL; X15373; G53569; -.
DR   EMBL; M75986; G198412; -.
DR   EMBL; M75987; G554171; -.
DR   PIR; S04844; ACMSIT.
DR   MGD; MGI:96623; ITPR1.
KW   RECEPTOR; TRANSMEMBRANE; GLYCOPROTEIN; PHOSPHORYLATION;
KW   ENDOPLASMIC RETICULUM; IONIC CHANNEL; ION TRANSPORT; CALCIUM CHANNEL;
KW   ALTERNATIVE SPLICING.
FT   DOMAIN        1   2273       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM   2274   2294       M1 (POTENTIAL).
FT   TRANSMEM   2308   2326       M2 (POTENTIAL).
FT   TRANSMEM   2334   2356       M3 (POTENTIAL).
FT   TRANSMEM   2365   2387       M4 (POTENTIAL).
FT   TRANSMEM   2391   2407       M5 (POTENTIAL).
FT   TRANSMEM   2440   2462       M6 (POTENTIAL).
FT   TRANSMEM   2530   2549       M7 (POTENTIAL).
FT   TRANSMEM   2570   2589       M8 (POTENTIAL).
FT   DOMAIN     2590   2749       CYTOPLASMIC (POTENTIAL).
FT   VARSPLIC    318    332       MISSING (IN INSP3R SI-).
FT   VARSPLIC   1692   1731       MISSING (IN INSP3R SIIABC-).
FT   VARSPLIC   1715   1715       MISSING (IN INSP3R SIIB-).
FT   VARSPLIC   1715   1731       MISSING (IN INSP3R SIIBC-).
FT   MOD_RES    1588   1588       PHOSPHORYLATION (BY CAPK) (POTENTIAL).
FT   MOD_RES    1755   1755       PHOSPHORYLATION (BY CAPK) (POTENTIAL).
SQ   SEQUENCE   2749 AA;  313193 MW;  B19B78F2 CRC32;
     MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL
     CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV
     RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE
     GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT
     SPLKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL
     VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE
     LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH
     NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT
     NADILIETKL VLSRFEFEGV STGENALEAG EDEEEVWLFW RDSNKEIRSK SVRELAQDAK
     EGQKEDRDIL SYYRYQLNLF ARMCLDRQYL AINEISGQLD VDLILRCMSD ENLPYDLRAS
     FCRLMLHMHV DRDPQEQVTP VKYARLWSEI PSEIAIDDYD SSGTSKDEIK ERFAQTMEFV
     EEYLRDVVCQ RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHV
     TTIFPISKMT KGEENKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA PEGNVKQAEP
     EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQSSE TSSGNSSQEG
     PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL
     QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD
     EPMDGASGEN EHKKTEEGTS KPLKHESTSS YNYRVVKEIL IRLSKLCVQE SASVRKSRKQ
     QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ NQALLHKHIN
     LFLKPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK FLQTIVKAEG
     KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP LMYHIHLVEL
     LAVCTEGKNV YTEIKCNSLL PLDDIVRVVT HEDCIPEVKI AYINFLNHCY VDTEVEMKEI
     YTSNHMWKLF ENFLVDICRA CNNTSDRKHA DSILEKYVTE IVMSIVTTFF SSPFSDQSTT
     LQTRQPVFVQ LLQGVFRVYH CNWLMPSQKA SVESCIRVLS DVAKSRAIAI PVDLDSQVNN
     LFLKSHNIVQ KTALNWRLSA RNAARRDSVL AASRDYRNII ERLQDIVSAL EDRLRPLVQA
     ELSVLVDVLH RPELLFPENT DARRKCESGG FICKLIKHTK QLLEENEEKL CIKVLQTLRE
     MMTKDRGYGE KQISIDESEN AELPQAPEAE NSTEQELEPS PPLRQLEDHK RGEALRQILV
     NRYYGNIRPS GRRESLTSFG NGPLSPGGPS KPGGGGGGPG SSSTSRGEMS LAEVQCHLDK
     EGASNLVIDL IMNASSDRVF HESILLAIAL LEGGNTTIQH SFFCRLTEDK KSEKFFKVFY
     DRMKVAQQEI KATVTVNTSD LGNKKKDDEV DRDAPSRKKA KEPTTQITEE VRDQLLEASA
     ATRKAFTTFR READPDDHYQ SGEGTQATTD KAKDDLEMSA VITIMQPILR FLQLLCENHN
     RDLQNFLRCQ NNKTNYNLVC ETLQFLDCIC GSTTGGLGLL GLYINEKNVA LINQTLESLT
     EYCQGPCHEN QNCIATHESN GIDIITALIL NDINPLGKKR MDLVLELKNN ASKLLLAIME
     SRHDSENAER ILYNMRPKEL VEVIKKAYMQ GEVEFEDGEN GEDGAASPRN VGHNIYILAH
     QLARHNKELQ TMLKPGGQVD GDEALEFYAK HTAQIEIVRL DRTMEQIVFP VPSICEFLTK
     ESKLRIYYTT ERDEQGSKIN DFFLRSEDLF NEMNWQKKLR AQPVLYWCAR NMSFWSSISF
     NLAVLMNLLV AFFYPFKGVR GGTLEPHWSG LLWTAMLISL AIVIALPKPH GIRALIASTI
     LRLIFSVGLQ PTLFLLGAFN VCNKIIFLMS FVGNCGTFTR GYRAMVLDVE FLYHLLYLLI
     CAMGLFVHEF FYSLLLFDLV YREETLLNVI KSVTRNGRSI ILTAVLALIL VYLFSIVGYL
     FFKDDFILEV DRLPNETAVP ETGESLANDF LYSDVCRVET GENCTSPAPK EELLPAEETE
     QDKEHTCETL LMCIVTVLSH GLRSGGGVGD VLRKPSKEEP LFAARVIYDL LFFFMVIIIV
     LNLIFGVIID TFADLRSEKQ KKEEILKTTC FICGLERDKF DNKTVTFEEH IKEEHNMWHY
     LCFIVLVKVK DSTEYTGPES YVAEMIRERN LDWFLRMRAM SLVSSDSEGE QNELRNLQEK
     LESTMKLVTN LSGQLSELKD QMTEQRKQKQ RIGLLGHPPH MNVNPQQPA
//