ID IP3R_MOUSE STANDARD; PRT; 2749 AA. AC P11881; DT 01-OCT-1989 (REL. 12, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-JUL-1993 (REL. 26, LAST ANNOTATION UPDATE) DE INOSITOL 1,4,5-TRISPHOSPHATE-BINDING PROTEIN TYPE 1 RECEPTOR DE (INOSITOL 1,4,5-TRISPHOSPHATE-BINDING PROTEIN P(400)) (TYPE 1 INSP3 DE RECEPTOR). GN INSP3R. OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=CERBELLA PURKINJE NEURONS; RX MEDLINE; 90044039. RA FURUICHI T., YOSHIKAWA S., MIYAWAKI A., WADA K., MAEDA N., RA MIKOSHIBA K.; RL NATURE 342:32-38(1989). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=ICR; TISSUE=CEREBELLUM; RX MEDLINE; 89345101. RA FURUICHI T., YOSHIKAWA S., MIKOSHIBA K.; RL NUCLEIC ACIDS RES. 17:5385-5386(1989). RN [3] RP ALTERNATIVE SPLICING. RX MEDLINE; 91296797. RA NAKAGAWA T., OKANO H., FURUICHI T., ARUGA J., MIKOSHIBA K.; RL PROC. NATL. ACAD. SCI. U.S.A. 88:6244-6248(1991). CC -!- FUNCTION: RECEPTOR FOR INOSITOL 1,4,5-TRISPHOSPHATE, A SECOND CC MESSENGER THAT MEDIATES THE RELEASE OF INTRACELLULAR CALCIUM. CC THE RECEPTOR CONTAINS A CALCIUM CHANNEL IN ITS C-TERMINAL CC EXTREMITY. ITS LARGE N-TERMINAL CYTOPLASMIC REGION HAS THE LIGAND- CC BINDING SITE IN THE N-TERMINUS AND MODULATORY SITES IN THE MIDDLE CC PORTION IMMEDIATELY UPSTREAM OF THE CHANNEL REGION. CC -!- SUBUNIT: HOMOTETRAMER. CC -!- PTM: PHOSPHORYLATED BY CYCLIC-AMP KINASE. PHOSPHORYLATION PREVENTS CC THE LIGAND-INDUCED OPENING OF THE CALCIUM CHANNELS. CC -!- CALCIUM APPEARS TO INHIBIT LIGAND BINDING TO THE RECEPTOR, MOST CC PROBABLY BY INTERACTING WITH A DISTINCT CALCIUM-BINDING PROTEIN CC WHICH THEN INHIBITS THE RECEPTOR. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. ENDOPLASMIC CC RETICULUM. CC -!- ALTERNATIVE PRODUCTS: ADDITIONAL SUBTYPES OF INSP3R ARISE BY CC ALTERNATIVE SPLICING OF THE SAME GENE. CC -!- SIMILARITY: TO RYANODINE RECEPTOR. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X15373; X15373. DR PIR; S04844; ACMSIT. KW RECEPTOR; TRANSMEMBRANE; GLYCOPROTEIN; PHOSPHORYLATION; KW ENDOPLASMIC RETICULUM; IONIC CHANNEL; ION TRANSPORT; CALCIUM CHANNEL; KW ALTERNATIVE SPLICING. FT DOMAIN 1 2273 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 2274 2294 M1 (POTENTIAL). FT TRANSMEM 2308 2326 M2 (POTENTIAL). FT TRANSMEM 2334 2356 M3 (POTENTIAL). FT TRANSMEM 2365 2387 M4 (POTENTIAL). FT TRANSMEM 2391 2407 M5 (POTENTIAL). FT TRANSMEM 2440 2462 M6 (POTENTIAL). FT TRANSMEM 2530 2549 M7 (POTENTIAL). FT TRANSMEM 2570 2589 M8 (POTENTIAL). FT DOMAIN 2590 2749 CYTOPLASMIC (POTENTIAL). FT VARSPLIC 318 332 MISSING (IN INSP3R SI-). FT VARSPLIC 1692 1731 MISSING (IN INSP3R SIIABC-). FT VARSPLIC 1715 1715 MISSING (IN INSP3R SIIB-). FT VARSPLIC 1715 1731 MISSING (IN INSP3R SIIBC-). FT MOD_RES 1588 1588 PHOSPHORYLATION (BY CAPK) (POTENTIAL). FT MOD_RES 1755 1755 PHOSPHORYLATION (BY CAPK) (POTENTIAL). SQ SEQUENCE 2749 AA; 313193 MW; 22837568 CN; MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVDPDQDAS RSRLRNAQEK MVYSLVSVPE GNDISSIFEL DPTTLRGGDS LVPRNSYVRL RHLCTNTWVH STNIPIDKEE EKPVMLKIGT SPLKEDKEAF AIVPVSPAEV RDLDFANDAS KVLGSIAGKL EKGTITQNER RSVTKLLEDL VYFVTGGTNS GQDVLEVVFS KPNRERQKLM REQNILKQIF KLLQAPFTDC GDGPMLRLEE LGDQRHAPFR HICRLCYRVL RHSQQDYRKN QEYIAKQFGF MQKQIGYDVL AEDTITALLH NNRKLLEKHI TAAEIDTFVS LVRKNREPRF LDYLSDLCVS MNKSIPVTQE LICKAVLNPT NADILIETKL VLSRFEFEGV STGENALEAG EDEEEVWLFW RDSNKEIRSK SVRELAQDAK EGQKEDRDIL SYYRYQLNLF ARMCLDRQYL AINEISGQLD VDLILRCMSD ENLPYDLRAS FCRLMLHMHV DRDPQEQVTP VKYARLWSEI PSEIAIDDYD SSGTSKDEIK ERFAQTMEFV EEYLRDVVCQ RFPFSDKEKN KLTFEVVNLA RNLIYFGFYN FSDLLRLTKI LLAILDCVHV TTIFPISKMT KGEENKGSNV MRSIHGVGEL MTQVVLRGGG FLPMTPMAAA PEGNVKQAEP EKEDIMVMDT KLKIIEILQF ILNVRLDYRI SCLLCIFKRE FDESNSQSSE TSSGNSSQEG PSNVPGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH DYPPLVSGAL QLLFRHFSQR QEVLQAFKQV QLLVTSQDVD NYKQIKQDLD QLRSIVEKSE LWVYKGQGPD EPMDGASGEN EHKKTEEGTS KPLKHESTSS YNYRVVKEIL IRLSKLCVQE SASVRKSRKQ QQRLLRNMGA HAVVLELLQI PYEKAEDTKM QEIMRLAHEF LQNFCAGNQQ NQALLHKHIN LFLKPGILEA VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRNVQYIK FLQTIVKAEG KFIKKCQDMV MAELVNSGED VLVFYNDRAS FQTLIQMMRS ERDRMDENSP LMYHIHLVEL LAVCTEGKNV YTEIKCNSLL PLDDIVRVVT HEDCIPEVKI AYINFLNHCY VDTEVEMKEI YTSNHMWKLF ENFLVDICRA CNNTSDRKHA DSILEKYVTE IVMSIVTTFF SSPFSDQSTT LQTRQPVFVQ LLQGVFRVYH CNWLMPSQKA SVESCIRVLS DVAKSRAIAI PVDLDSQVNN LFLKSHNIVQ KTALNWRLSA RNAARRDSVL AASRDYRNII ERLQDIVSAL EDRLRPLVQA ELSVLVDVLH RPELLFPENT DARRKCESGG FICKLIKHTK QLLEENEEKL CIKVLQTLRE MMTKDRGYGE KQISIDESEN AELPQAPEAE NSTEQELEPS PPLRQLEDHK RGEALRQILV NRYYGNIRPS GRRESLTSFG NGPLSPGGPS KPGGGGGGPG SSSTSRGEMS LAEVQCHLDK EGASNLVIDL IMNASSDRVF HESILLAIAL LEGGNTTIQH SFFCRLTEDK KSEKFFKVFY DRMKVAQQEI KATVTVNTSD LGNKKKDDEV DRDAPSRKKA KEPTTQITEE VRDQLLEASA ATRKAFTTFR READPDDHYQ SGEGTQATTD KAKDDLEMSA VITIMQPILR FLQLLCENHN RDLQNFLRCQ NNKTNYNLVC ETLQFLDCIC GSTTGGLGLL GLYINEKNVA LINQTLESLT EYCQGPCHEN QNCIATHESN GIDIITALIL NDINPLGKKR MDLVLELKNN ASKLLLAIME SRHDSENAER ILYNMRPKEL VEVIKKAYMQ GEVEFEDGEN GEDGAASPRN VGHNIYILAH QLARHNKELQ TMLKPGGQVD GDEALEFYAK HTAQIEIVRL DRTMEQIVFP VPSICEFLTK ESKLRIYYTT ERDEQGSKIN DFFLRSEDLF NEMNWQKKLR AQPVLYWCAR NMSFWSSISF NLAVLMNLLV AFFYPFKGVR GGTLEPHWSG LLWTAMLISL AIVIALPKPH GIRALIASTI LRLIFSVGLQ PTLFLLGAFN VCNKIIFLMS FVGNCGTFTR GYRAMVLDVE FLYHLLYLLI CAMGLFVHEF FYSLLLFDLV YREETLLNVI KSVTRNGRSI ILTAVLALIL VYLFSIVGYL FFKDDFILEV DRLPNETAVP ETGESLANDF LYSDVCRVET GENCTSPAPK EELLPAEETE QDKEHTCETL LMCIVTVLSH GLRSGGGVGD VLRKPSKEEP LFAARVIYDL LFFFMVIIIV LNLIFGVIID TFADLRSEKQ KKEEILKTTC FICGLERDKF DNKTVTFEEH IKEEHNMWHY LCFIVLVKVK DSTEYTGPES YVAEMIRERN LDWFLRMRAM SLVSSDSEGE QNELRNLQEK LESTMKLVTN LSGQLSELKD QMTEQRKQKQ RIGLLGHPPH MNVNPQQPA //