ID OTC$MOUSE STANDARD; PRT; 354 AA. AC P11725; DT 01-OCT-1989 (REL. 12, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-APR-1990 (REL. 14, LAST ANNOTATION UPDATE) DE ORNITHINE CARBAMOYLTRANSFERASE PRECURSOR (EC 2.1.3.3) (OTC). OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=C57BL/6J; RC MEDLINE=87263407; RA VERES G., GIBBS R.A., SCHERER S.E., CASKEY C.T.; RL SCIENCE 237:415-417(1987). RN [2] RP SEQUENCE FROM N.A. RC MEDLINE=88157717; RA SCHERER S.E., VERES G., CASKEY C.T.; RL NUCLEIC ACIDS RES. 16:1593-1601(1988). RN [3] RP SEQUENCE OF 1-26 FROM N.A. RC STRAIN=C57BL/6J; RC MEDLINE=86224037; RA VERES G., CRAIGEN W.J., CASKEY C.T.; RL J. BIOL. CHEM. 261:7588-7591(1986). CC -!- CATALYTIC ACTIVITY: CARBAMOYL PHOSPHATE + ORNITHINE = CITRULLINE CC + ORTHOPHOSPHATE. CC -!- PATHWAY: SECOND STEP IN UREA CYCLE, ARGININE BIOSYNTHESIS. CC -!- SUBUNIT: TRIMER OF IDENTICAL CHAINS. CC -!- SUBCELLULAR LOCATION: MITOCHONDRIAL MATRIX. CC -!- DISEASE: SPARSE FUR (SPF) MOUSE HAVE AN OTC WITH AN OVERALL CC DECREASE IN ACTIVITY, AND ALTERED SUBSTRATE AFFINITY. CC -!- SIMILARITY: STRONG TO ALL OTHER OTCASES, ALSO HIGH TO ATCASES. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M17030; MMOTCA. DR EMBL; M12716; MMOTC1. DR EMBL; X07092; MMOCT1. DR EMBL; X07093; MMOCT2. DR EMBL; X07094; MMOCT3. DR EMBL; X07095; MMOCT4. DR EMBL; X07096; MMOCT5. DR EMBL; X07097; MMOCT6. DR EMBL; X07098; MMOCT78. DR EMBL; X07099; MMOCT9. DR EMBL; X07100; MMOCT10. DR PIR; S03407; S03407. DR PROSITE; PS00097; CARBAMOYLTRANSFERASE. KW ARGININE BIOSYNTHESIS; UREA CYCLE; TRANSFERASE; MITOCHONDRION; KW TRANSIT PEPTIDE. FT TRANSIT 1 32 MITOCHONDRION. FT CHAIN 33 354 ORNITHINE CARBAMOYLTRANSFERASE. FT VARIANT 117 117 H -> N (IN SPARSE FUR MOUSE). FT CONFLICT 195 195 G -> R (IN REF. 2). SQ SEQUENCE 354 AA; 39765 MW; 673396 CN; MLSNLRILLN NAALRKGHTS VVRHFWCGKP VQSQVQLKGR DLLTLKNFTG EEIQYMLWLS ADLKFRIKQK GEYLPLLQGK SLGMIFEKRS TRTRLSTETG FALLGGHPSF LTTQDIHLGV NESLTDTARV LSSMTDAVLA RVYKQSDLDT LAKEASIPIV NGLSDLYHPI QILADYLTLQ EHYGSLKGLT LSWIGDGNNI LHSIMMSAAK FGMHLQAATP KGYEPDPNIV KLAEQYAKEN GTKLSMTNDP LEAARGGNVL ITDTWISMGQ EDEKKKRLQA FQGYQVTMKT AKVAASDWTF LHCLPRKPEE VDDEVFYSPR SLVFPEAENR KWTIMAVMVS LLTDYSPVLQ KPKF //