ID HBB2_TRICR Reviewed; 145 AA. AC P10786; DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1989, sequence version 1. DT 26-JUN-2013, entry version 71. DE RecName: Full=Hemoglobin subunit beta-2; DE AltName: Full=Beta-2-globin; DE AltName: Full=Hemoglobin beta-2 chain; DE AltName: Full=Hemoglobin beta-minor chain; GN Name=HBB2; OS Triturus cristatus (Great crested newt) (Warty newt). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Caudata; Salamandroidea; Salamandridae; OC Pleurodelinae; Triturus. OX NCBI_TaxID=8323; RN [1] RP PROTEIN SEQUENCE. RX PubMed=3242554; RA Kleinschmidt T., Sgouros J.G., Braunitzer G.; RT "The first sequenced normal hemoglobin lacking histidine in position RT 146 of the beta-chains. The primary structures of the major and minor RT hemoglobin components of the great crested newt (Triturus cristatus, RT Urodela, Amphibia)."; RL Biol. Chem. Hoppe-Seyler 369:1343-1360(1988). CC -!- FUNCTION: Involved in oxygen transport from the lung to the CC various peripheral tissues. CC -!- SUBUNIT: Minor hemoglobin is a tetramer of two alpha-2 chains and CC two beta-2 chains. CC -!- TISSUE SPECIFICITY: Red blood cells. CC -!- SIMILARITY: Belongs to the globin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; S02027; S02027. DR ProteinModelPortal; P10786; -. DR HOVERGEN; HBG009709; -. DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW. DR Gene3D; 1.10.490.10; -; 1. DR InterPro; IPR000971; Globin. DR InterPro; IPR009050; Globin-like. DR InterPro; IPR012292; Globin_dom. DR InterPro; IPR002337; Haemoglobin_b. DR PANTHER; PTHR11442:SF7; PTHR11442:SF7; 1. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00814; BETAHAEM. DR SUPFAM; SSF46458; Globin_like; 1. DR PROSITE; PS01033; GLOBIN; 1. PE 1: Evidence at protein level; KW Direct protein sequencing; Heme; Iron; Metal-binding; KW Oxygen transport; Transport. FT CHAIN 1 145 Hemoglobin subunit beta-2. FT /FTId=PRO_0000053139. FT METAL 63 63 Iron (heme distal ligand). FT METAL 92 92 Iron (heme proximal ligand). SQ SEQUENCE 145 AA; 16218 MW; 04C8F25E427BAAC5 CRC64; VHLTAEDRKE IAAILGKVNV DSLGGQCLAR LIVVNPWSRR YFHDFGDLSS CDAICRNPKV LAHGAKVMRS IVEATKHLDN LREYYADLSV THSLKFYVDP ENFKLFSGIV IVCLALTLQT DFSCHKQLAF EKLMKGVSHA LGHGY //