ID AMID$BOVIN STANDARD; PRT; 962 AA. AC P10731; DT 01-JUL-1989 (REL. 11, CREATED) DT 01-JUL-1989 (REL. 11, LAST SEQUENCE UPDATE) DT 01-JUL-1989 (REL. 11, LAST ANNOTATION UPDATE) DE PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE PRECURSOR DE (EC 1.14.17.3) (PAM). OS BOVINE (BOS TAURUS). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; ARTIODACTYLA. RN [1] (SEQUENCE FROM N.A.) RA EIPPER B.A., PARK L.P., DICKERSON I.M., KEUTMANN H.T., THIELE E.A., RA RODRIGUEZ H., SCHOFIELD P.R., MAINS R.E.; RL MOL. ENDOCRINOL. 1:777-790(1987). CC -!- FUNCTION: C-TERMINAL ALPHA-AMIDATION OF PEPTIDES. CC -!- CATALYTIC ACTIVITY: PEPTIDYLGLYCINE + ASCORBATE + O(2) = CC PEPTIDYL(2-HYDROXYGLYCINE) + DEHYDROASCORBATE + H(2)O. CC (THE PRODUCT IS UNSTABLE AND DISMUTATES TO GLYOXYLATE AND THE CC CORRESPONDING DESGLYCINE PEPTIDE AMIDE). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M18683; BTPAMA. KW OXIDOREDUCTASE; MONOOXYGENASE; SIGNAL. FT SIGNAL 1 30 PUTATIVE. FT CHAIN 31 962 PEPTIDYL-GLYCINE ALPHA-AMIDATING FT MONOOXYGENASE. SQ SEQUENCE 962 AA; 106957 MW; 4907707 CN; MAGFRSLLVL LLVFPSGCVG FKETTRSFSN ECLGTTRPVI PIDSSDFALD IRMPGVTPKQ SDTYFCMSVR LPMDEEAFVI DFKPRASMDT VHHMLLFGCN MPASTGNYWF CDEGTCTDKA NILYAWARNA PPTRLPKGVG FRVGGETGSK YFVLQVHYGD ISAFRDNHKD CSGVSLHLTR LPQPLIAGMY LMMSVDTVIP PGGKVVNSDI SCHYKKYPMH VFAYRVHTHH LGKVVSGYRV RNGQWTLIGR QSPQLPQAFY PVEHPVDVSF GDILAARCVF TGEGRTEVTH IGGTSSDEMC NLYIMYYMEA KHAVSFMTCT QNVAPDIFRT IPPEANIPIP VKSDMVMMHG HHKETENKDK TSLLQQPKRE EEGVLEQGDF YSLLSKLLGE REDVVHVHKY NPTEKAESES DLVAEIANVV QKKDLGRSDT RESAEQERGN AILVRDRIHK FHRLVSTLRP AESRVLSLQQ PLPGEGTWEP EHTGDFHVEE ALDWPGVYLL PGQVSGVALD PQNNLVIFHR GDHVWDGNSF DSKFVYQQRG LGPIEEDTIL VIDPNNAAVL QSSGKNLFYL PHGLSIDKDG NYWVTDVALH QVFKLDPKSK EGPLLTLGRS MQPGSDQNHF CQPTDVAVDP DTGTIYVSDG YCNSRLVQFS PSGKFITQWG EASLESSPKP GQFRVPHSLA LVPPLGQLCV ADRENGRIQC FKTDTKEFVR EIKHPSFGRN VFAISYIPGL LFAVNGKPYF EDQEPVQGFV MNFSSGEIID VFKPVRKHFD MPHDIAASED GTVYVGDAHT NTVWKFTSTE KMEHRSVKKA GIEVQEIKES EAVVETKMEN KPASSELQKI QEKQKLVKEP GSGVPAVLIT TLLVIPVVVL LAIALFIRWK KSRAFGDSER KLEASSGRVL GRLRGKGGGG LNLGNFFASR KGYSRKGFDR LSTEGSDQEK DEDASESEEE YSAPPPAPAP SS //