ID HBA_SPHPU STANDARD; PRT; 141 AA. AC P10059; DT 01-MAR-1989 (REL. 10, CREATED) DT 01-MAR-1989 (REL. 10, LAST SEQUENCE UPDATE) DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE) DE HEMOGLOBIN ALPHA-A CHAIN. OS SPHENODON PUNCTATUS (HATTERIA) (TUATARA). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; REPTILIA; OC RHYNCHOCEPHALIA. RN [1] RP SEQUENCE. RM 89105321 RA ABBASI A., WELLS R.M.G., BRITTAIN T., BRAUNITZER G.; RL BIOL. CHEM. HOPPE-SEYLER 369:755-764(1988). CC -!- SUBUNIT: THERE ARE THREE FORMS OF HEMOGLOBIN IN SPHENODON: A, A' CC AND D. HB A IS A TETRAMER OF TWO ALPHA-A AND TWO BETA-1, HB A' IS CC A TETRAMER OF TWO ALPHA-A AND TWO BETA-2, HB D IS A TETRAMER OF CC TWO ALPHA-D AND TWO BETA-2. CC -!- SPHENODON`S HBS HAVE PROPERTIES NOT FOUND IN OTHER REPTILES: POOR CC COOPERATIVITY, HIGH AFFINITY FOR OXYGENE, SMALL BOHR AND HALDANE CC EFFECTS, APPRECIABLE PHOSPHATE EFFECTS. (THOSE PROPERTIES ARE ALSO CC FOUND IN THE HBS OF PRIMITIVE URODELE AND CAECILIAN AMPHIBIANS). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; S01136; HATJA. DR PROSITE; PS01033; GLOBIN. KW HEME; OXYGEN TRANSPORT; RESPIRATORY PROTEIN; ERYTHROCYTE. FT METAL 58 58 IRON (HEME DISTAL LIGAND). FT METAL 87 87 IRON (HEME PROXIMAL LIGAND). SQ SEQUENCE 141 AA; 15454 MW; 104140 CN; MLSASDKANV KAIWSKVCVH AEEYGAETLE RMFTVYPSTK TYFPHFDLTH GSAQVKAHGK KVVNAMGEAV NHLDDMAGAL LKLSDLHAQK LRVDPVNFKL LAQCFLVVLG VHHPAALTPE VHASLDKFLC AVGLVLTAKY R //