ID HBA_SPHPU STANDARD; PRT; 141 AA. AC P10059; DT 01-MAR-1989 (Rel. 10, Created) DT 01-MAR-1989 (Rel. 10, Last sequence update) DT 29-MAR-2004 (Rel. 43, Last annotation update) DE Hemoglobin alpha-A chain. GN HBAA. OS Sphenodon punctatus (Hatteria) (Tuatara). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Lepidosauria; Sphenodontia; Sphenodontidae; Sphenodon. OX NCBI_TaxID=8508; RN [1] RP SEQUENCE. RX MEDLINE=89105321; PubMed=3214555; RA Abbasi A., Wells R.M.G., Brittain T., Braunitzer G.; RT "Primary structure of the hemoglobins from Sphenodon (Sphenodon RT punctatus, Tuatara, Rynchocephalia). Evidence for the expression of RT alpha D-gene."; RL Biol. Chem. Hoppe-Seyler 369:755-764(1988). CC -!- FUNCTION: Involved in oxygen transport from the lung to the CC various peripheral tissues. CC -!- SUBUNIT: There are three forms of hemoglobin in Sphenodon: A, A' CC and D. Hb A is a tetramer of two alpha-A and two beta-1, Hb A' is CC a tetramer of two alpha-a and two beta-2, Hb D is a tetramer of CC two alpha-D and two beta-2. CC -!- TISSUE SPECIFICITY: Red blood cells. CC -!- MISCELLANEOUS: Sphenodon`s Hbs have properties not found in other CC reptiles: poor cooperativity, high affinity for oxygen, small Bohr CC and haldane effects, appreciable phosphate effects (those CC properties are also found in the Hbs of primitive urodele and CC caecilian amphibians). CC -!- SIMILARITY: Belongs to the globin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; S01136; HATJA. DR HSSP; P01990; 1A4F. DR InterPro; IPR002338; Alpha_haem. DR InterPro; IPR000971; Globin. DR Pfam; PF00042; globin; 1. DR PRINTS; PR00612; ALPHAHAEM. DR PROSITE; PS01033; GLOBIN; 1. KW Heme; Oxygen transport; Transport; Erythrocyte. FT METAL 58 58 Iron (heme distal ligand). FT METAL 87 87 Iron (heme proximal ligand). SQ SEQUENCE 141 AA; 15454 MW; F72D8BDD2D25C501 CRC64; MLSASDKANV KAIWSKVCVH AEEYGAETLE RMFTVYPSTK TYFPHFDLTH GSAQVKAHGK KVVNAMGEAV NHLDDMAGAL LKLSDLHAQK LRVDPVNFKL LAQCFLVVLG VHHPAALTPE VHASLDKFLC AVGLVLTAKY R //