ID ZTRF1_HUMAN Reviewed; 404 AA. AC P0DTL6; B3KSX0; D3DWM3; E9PJD7; Q6ZMK1; Q9BSF6; Q9BSU6; DT 12-OCT-2022, integrated into UniProtKB/Swiss-Prot. DT 12-OCT-2022, sequence version 1. DT 24-JUL-2024, entry version 11. DE RecName: Full=Zinc finger TRAF-type-containing protein 1 {ECO:0000305}; DE AltName: Full=Cysteine and histidine-rich protein 1; GN Name=ZFTRAF1 {ECO:0000312|HGNC:HGNC:17806}; Synonyms=CYHR1, KIAA0496; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RC TISSUE=Brain; RX PubMed=9455484; DOI=10.1093/dnares/4.5.345; RA Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., RA Nomura N., Ohara O.; RT "Characterization of cDNA clones in size-fractionated cDNA libraries from RT human brain."; RL DNA Res. 4:345-349(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Brain cortex, and Spleen; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., RA Platzer M., Shimizu N., Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-404 (ISOFORM 1). RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBUNIT: Interacts with LGALS3. {ECO:0000250|UniProtKB:Q9QXA1}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QXA1}. CC Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9QXA1}. CC Note=Shows a prominent perinuclear and cytoplasmic localization. CC {ECO:0000250|UniProtKB:Q9QXA1}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=5; CC IsoId=P0DTL6-5; Sequence=Displayed; CC Name=1; CC IsoId=P0DTL6-1, Q6ZMK1-1; CC Sequence=VSP_061633; CC Name=2; CC IsoId=P0DTL6-2, Q6ZMK1-2; CC Sequence=VSP_061632; CC Name=4; CC IsoId=P0DTL6-4, Q6ZMK1-4; CC Sequence=VSP_061632, VSP_061634, VSP_061635; CC -!- SIMILARITY: Belongs to the ZFTRAF1 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAD18724.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB007965; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AK094514; BAG52882.1; -; mRNA. DR EMBL; AK160381; BAD18724.1; ALT_INIT; mRNA. DR EMBL; AC084125; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471162; EAW82088.1; -; Genomic_DNA. DR EMBL; CH471162; EAW82089.1; -; Genomic_DNA. DR EMBL; BC004544; AAH04544.2; -; mRNA. DR CCDS; CCDS83335.1; -. [P0DTL6-5] DR RefSeq; NP_001123360.1; NM_001129888.1. DR RefSeq; NP_001317547.1; NM_001330618.1. [P0DTL6-5] DR RefSeq; NP_116076.1; NM_032687.3. DR RefSeq; NP_612505.1; NM_138496.1. [P0DTL6-1] DR RefSeq; XP_006716623.1; XM_006716560.3. DR RefSeq; XP_006716624.1; XM_006716561.3. DR RefSeq; XP_011515353.1; XM_011517051.1. DR IntAct; P0DTL6; 10. DR iPTMnet; P0DTL6; -. DR PhosphoSitePlus; P0DTL6; -. DR BioMuta; CYHR1; -. DR DMDM; 182641989; -. DR jPOST; Q6ZMK1; -. DR PeptideAtlas; P0DTL6; -. DR ProteomicsDB; 21106; -. DR Antibodypedia; 52728; 23 antibodies from 11 providers. DR DNASU; 50626; -. DR Ensembl; ENST00000530374.6; ENSP00000433769.1; ENSG00000187954.14. [P0DTL6-5] DR GeneID; 157542; -. DR GeneID; 50626; -. DR GeneID; 84773; -. DR KEGG; hsa:157542; -. DR KEGG; hsa:50626; -. DR KEGG; hsa:84773; -. DR MANE-Select; ENST00000530374.6; ENSP00000433769.1; NM_001330618.2; NP_001317547.1. DR AGR; HGNC:17806; -. DR AGR; HGNC:56235; -. DR AGR; HGNC:56752; -. DR CTD; 157542; -. DR CTD; 50626; -. DR CTD; 84773; -. DR DisGeNET; 157542; -. DR DisGeNET; 50626; -. DR DisGeNET; 84773; -. DR GeneCards; ZFTRAF1; -. DR HGNC; HGNC:17806; ZFTRAF1. DR MalaCards; ZFTRAF1; -. DR MIM; 616635; gene. DR neXtProt; NX_Q6ZMK1; -. DR OpenTargets; ENSG00000187954; -. DR VEuPathDB; HostDB:ENSG00000187954; -. DR eggNOG; KOG3002; Eukaryota. DR GeneTree; ENSGT00390000018258; -. DR OMA; RTDEFIH; -. DR OrthoDB; 5491349at2759; -. DR PhylomeDB; Q6ZMK1; -. DR TreeFam; TF324281; -. DR PathwayCommons; Q6ZMK1; -. DR SignaLink; Q6ZMK1; -. DR BioGRID-ORCS; 50626; 29 hits in 1157 CRISPR screens. DR ChiTaRS; CYHR1; human. DR GenomeRNAi; 50626; -. DR PRO; PR:P0DTL6; -. DR Proteomes; UP000005640; Chromosome 8. DR Bgee; ENSG00000187954; Expressed in right hemisphere of cerebellum and 179 other cell types or tissues. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR CDD; cd22861; CYHR1_C; 1. DR CDD; cd16505; RING-HC_CYHR1; 1. DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2. DR InterPro; IPR039338; ZFTRAF1. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR InterPro; IPR001293; Znf_TRAF. DR PANTHER; PTHR23059; CYSTEINE AND HISTIDINE-RICH PROTEIN 1; 1. DR PANTHER; PTHR23059:SF4; CYSTEINE AND HISTIDINE-RICH PROTEIN 1; 1. DR SUPFAM; SSF57850; RING/U-box; 1. DR SUPFAM; SSF49599; TRAF domain-like; 1. DR PROSITE; PS50089; ZF_RING_2; 1. DR PROSITE; PS50145; ZF_TRAF; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cytoplasm; Metal-binding; Proteomics identification; KW Reference proteome; Zinc; Zinc-finger. FT CHAIN 1..404 FT /note="Zinc finger TRAF-type-containing protein 1" FT /id="PRO_0000328852" FT ZN_FING 111..156 FT /note="RING-type; degenerate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175" FT ZN_FING 152..225 FT /note="TRAF-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207" FT REGION 1..22 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 1..130 FT /note="Missing (in isoform 4 and isoform 2)" FT /id="VSP_061632" FT VAR_SEQ 1..124 FT /note="MSGAEEAGGGGPAAGPAGSVPAGVGVGVGAGPGAAAGQAAAAALGEAAGPGL FT PDEAGLAGARQLQLQEAAGDPDAPPKKRLRAAEAAEAAAAAAAAGSGKLEERLYSVLCC FT TVCLDLPKASVYQ -> MAPKPGAEWSTALSHLVLGVVSLHAAVSTAEASRGAAAGFLL FT QVLAATTTLAPGLSTHEDCLAGAWVATVIGLPLLAFDFHW (in isoform 1)" FT /id="VSP_061633" FT VAR_SEQ 275..333 FT /note="EVQFRPYRTDDFITRLYYETPRFTVLNQTWVLKARVNDSERNPNLSCKRTLS FT FQLLLKS -> GEAPRRLLHATQVWVGGLAARSLGAAGSGHWALTAPDSRALDKLPVDR FT WTPRSRRQAGD (in isoform 4)" FT /id="VSP_061634" FT VAR_SEQ 334..404 FT /note="Missing (in isoform 4)" FT /id="VSP_061635" SQ SEQUENCE 404 AA; 43813 MW; 0A272CC6662AF5F9 CRC64; MSGAEEAGGG GPAAGPAGSV PAGVGVGVGA GPGAAAGQAA AAALGEAAGP GLPDEAGLAG ARQLQLQEAA GDPDAPPKKR LRAAEAAEAA AAAAAAGSGK LEERLYSVLC CTVCLDLPKA SVYQCTNGHL MCAGCFIHLL ADARLKEEQA TCPNCRCEIS KSLCCRNLAV EKAVSELPSE CGFCLRQFPR SLLERHQKEE CQDRVTQCKY KRIGCPWHGP FHELTVHEAA CAHPTKTGSE LMEILDGMDQ SHRKEMQLYN SIFSLLSFEK IGYTEVQFRP YRTDDFITRL YYETPRFTVL NQTWVLKARV NDSERNPNLS CKRTLSFQLL LKSKVTAPLE CSFLLLKGPY DDVRISPVIY HFVFTNESNE TDYVPLPIID SVECNKLLAA KNINLRLFLF QIQK //